Coxibs and their aftermath: An (opinionated) commentary, based on some historical viewpoints

Whitehouse, M. (2005) Coxibs and their aftermath: An (opinionated) commentary, based on some historical viewpoints. Inflammopharmacology, 13 4: 403-417. doi:10.1163/156856005774415600


Author Whitehouse, M.
Title Coxibs and their aftermath: An (opinionated) commentary, based on some historical viewpoints
Journal name Inflammopharmacology   Check publisher's open access policy
ISSN 0925-4692
1568-5608
Publication date 2005-09
Sub-type Article (original research)
DOI 10.1163/156856005774415600
Volume 13
Issue 4
Start page 403
End page 417
Total pages 15
Editor K. D. Rainsford
Place of publication Basel, Switzerland
Publisher Birkhaeuser
Collection year 2005
Language eng
Subject C1
320599 Pharmacology not elsewhere classified
730118 Organs, diseases and abnormal conditions not elsewhere classified
1115 Pharmacology and Pharmaceutical Sciences
Formatted abstract
Five historical viewpoints are presented, each foreshadowing to some degree that it was only a matter of time before we would (re)learn that imbalanced anti-prostanoid therapy was a potentially lethal strategy. Positive outcomes from this coxib debacle might be more willingness to (i) acknowledge our lack of understanding concerning normal homeostatic mechanisms involving the autopharmacology and pleiotropic functions of prostanoids and acyclic eicosanoids (leukotrienes, lipoxins, resolvins, etc.); (ii) revisit the question of salicylate versus aspirin for therapies not requiring anti-thrombotic prophylaxis; (iii) re-examine some leads provided by natural/alternate therapies for inflammatory disorders; and (iv) reconsider the downside of over-reliance upon the present patent system as the main shield and driver of drug innovation.
Keyword Aspirin
Alternative Remedies
Coxibs
Homeostasis/Resoleomics
Pentoxifylline
Salicylates
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 06:29:52 EST