Relation of diet to cardiovascular disease risk factors in subjects with cardiovascular disease in Australia and New Zealand: analysis of the Long-Term Intervention with Pravastatin in Ischaemic Disease trial

Nestel, Paul J., Baghurst, Katrine, Colquhoun, David M., Simes, R. John, Mehalski, Kirsty, White, Harvey D., Tonkin, Andrew M., Kirby, Adrienne, Pollicino, Christine and Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Investigators (2005) Relation of diet to cardiovascular disease risk factors in subjects with cardiovascular disease in Australia and New Zealand: analysis of the Long-Term Intervention with Pravastatin in Ischaemic Disease trial. American Journal of Clinical Nutrition, 81 6: 1322-1329.


Author Nestel, Paul J.
Baghurst, Katrine
Colquhoun, David M.
Simes, R. John
Mehalski, Kirsty
White, Harvey D.
Tonkin, Andrew M.
Kirby, Adrienne
Pollicino, Christine
Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Investigators
Title Relation of diet to cardiovascular disease risk factors in subjects with cardiovascular disease in Australia and New Zealand: analysis of the Long-Term Intervention with Pravastatin in Ischaemic Disease trial
Journal name American Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 0002-9165
Publication date 2005
Sub-type Article (original research)
Volume 81
Issue 6
Start page 1322
End page 1329
Total pages 8
Editor C. Halsted
D. Finley
S. Schlicker
Place of publication USA
Publisher American Society for Clinical Nutrition, Inc
Collection year 2005
Language eng
Subject C1
321205 Nutrition and Dietetics
730215 Nutrition
Formatted abstract
Background: Comparisons of the relation of diet with coronary heart disease (CHD) between countries with similar socioeconomic environments have been few. Patients in Australia and New Zealand (n = 9014) who participated in a large secondary prevention trial had significantly different CHD mortality rates.

Objective: The objective of this study was to ascertain the effects of nutrient consumption on cardiovascular disease risk in patients from the 2 countries.

Design: Nutrient consumption patterns were surveyed in a subgroup of 1077 patients on 3 occasions over 4 y during an intervention trial with a statin.

Results: Within the entire cohort of 9014 patients, the New Zealanders had significantly (40%) more cardiovascular deaths than did the Australians. In the subgroup of 1077 patients, the New Zealanders were found at entry to have eaten significantly more total (69.34 ± 12.35 compared with 66.45 ± 12.9 g/d) and saturated (26.23 ± 8.41 compared with 24.37 ± 7.36 g/d) fat (P < 0.001 for each) and to have significantly (4%) higher concentrations of LDL cholesterol (3.96 ± 0.74 compared with 3.8 ± 0.76 mmol/L; P < 0.001) than did the Australians. At baseline, patients with previous coronary artery bypass grafting had diets that were significantly different from those of patients without previous coronary artery bypass grafting. Relations between nutrients and plasma lipids confirmed the direct effects of saturated fatty acids on LDL cholesterol and of alcohol on plasma triacylglycerol and HDL cholesterol. Dietary counseling throughout the trial led to significant improvements in compliance with guidelines. However, neither the baseline nor the improved 1-y nutrient intakes predicted future changes in cardiovascular events.

Conclusion: Differences in CHD mortality and in LDL-cholesterol concentrations between 2 populations with similar socioeconomic and cultural backgrounds were consistent with the amounts and types of fats eaten.
Keyword Nutrition & Dietetics
Total Fat
Saturated Fat
Cardiovascular Events
Ldl Cholesterol
Population Comparison
Clinical Trial
Coronary-heart-disease
Cholesterol
Prevention
Death
Mortality
Women
Men
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2006 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 06:28:36 EST