(+)-Echinobetaine B: isolation, structure elucidation, synthesis and preliminary SAR studies on a new nematocidal betaine from a southern Australian marine sponge, Echinodictyum sp.

Capon, R. J., Vuong, D., McNally, M., Peterle, T., Trotter, N., Lacey, E. and Gill, J. H. (2005) (+)-Echinobetaine B: isolation, structure elucidation, synthesis and preliminary SAR studies on a new nematocidal betaine from a southern Australian marine sponge, Echinodictyum sp.. Organic & Biomolecular Chemistry, 3 1: 118-122. doi:10.1039/b414839h


Author Capon, R. J.
Vuong, D.
McNally, M.
Peterle, T.
Trotter, N.
Lacey, E.
Gill, J. H.
Title (+)-Echinobetaine B: isolation, structure elucidation, synthesis and preliminary SAR studies on a new nematocidal betaine from a southern Australian marine sponge, Echinodictyum sp.
Journal name Organic & Biomolecular Chemistry   Check publisher's open access policy
ISSN 1477-0520
Publication date 2005
Sub-type Article (original research)
DOI 10.1039/b414839h
Open Access Status Not Open Access
Volume 3
Issue 1
Start page 118
End page 122
Total pages 5
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2005
Language eng
Abstract The principle nematocidal agent present in a southern Australian marine sponge of the genus Echinodictyum has been isolated and identfied as the novel betaine (+)-echinobetaine B (6), and the structure assigned by spectroscopic analysis has been confirmed by total synthesis. Preliminary SAR conclusions are drawn from analysis of synthetic intermediates and the known marine metabolites zooanemonin (12) and norzooanemonin (13), and the new sponge metabolite norzooanemonin methyl ester (14). The latter compound is reported for the first time from a selection of Australian sponges, including an Axinyssa sp., a Niphates sp., an Axinella sp. and a Ptilocaulis sp.
Keyword Chemistry, Organic
Exchange
Cyanotrimethylsilane
Enzymes
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 06:27:41 EST