ATM signaling and genornic stability in response to DNA damage

Lavin, Martin F., Birrell, Geoff, Chen, Philip, Kozlov, Sergei, Scott, Shaun and Gueven, Nuri (2005) ATM signaling and genornic stability in response to DNA damage. Mutation Research-fundamental And Molecular Mechanisms of Mutagenesis, 569 1-2: 123-132. doi:10.1016/j.mrfmmm.2004.04.020


Author Lavin, Martin F.
Birrell, Geoff
Chen, Philip
Kozlov, Sergei
Scott, Shaun
Gueven, Nuri
Title ATM signaling and genornic stability in response to DNA damage
Journal name Mutation Research-fundamental And Molecular Mechanisms of Mutagenesis
ISSN 0027-5107
1386-1964
Publication date 2005-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.mrfmmm.2004.04.020
Volume 569
Issue 1-2
Start page 123
End page 132
Total pages 10
Editor P. J. Stambrook
L. H. F. Mullenders
L. R. Ferguson
Place of publication Amsterdam, Netherlands
Publisher Elsevier Science Bv
Collection year 2005
Language eng
Subject C1
270103 Protein Targeting and Signal Transduction
730107 Inherited diseases (incl. gene therapy)
Abstract DNA double strand breaks represent the most threatening lesion to the integrity of the genome in cells exposed to ionizing radiation and radiomimetic chemicals. Those breaks are recognized, signaled to cell cycle checkpoints and repaired by protein complexes. The product of the gene (ATM) mutated in the human genetic disorder ataxia-telangietasia (A-T) plays a central role in the recognition and signaling of DNA damage. ATM is one of an ever growing number of proteins which when mutated compromise the stability of the genome and predispose to tumour development. for recognising double strand breaks in DNA, maintaining genome stability and minimizing risk of cancer are discussed. (C) 2004 Published by Elsevier B.V.
Keyword Atm Signaling
Genomic Stability
Ataxia-telangiectasia
Biotechnology & Applied Microbiology
Genetics & Heredity
Toxicology
Double-strand Breaks
Ataxia-telangiectasia Heterozygotes
S-phase Checkpoint
Cell-cycle
Homologous Recombination
Saccharomyces-cerevisiae
Mre11 Phosphorylation
Ionizing-radiation
Genomic Instability
Missense Mutations
Q-Index Code C1
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 16:26:52 EST