Behavioural characterization of Vitamin D receptor knockout mice

Burne, T. H. J., McGrath, J. J., Eyles, D. W. and Mackay-Sim, A. (2005) Behavioural characterization of Vitamin D receptor knockout mice. Behavioural Brain Research, 157 2: 299-308. doi:10.1016/j.bbr.2004.07.008


Author Burne, T. H. J.
McGrath, J. J.
Eyles, D. W.
Mackay-Sim, A.
Title Behavioural characterization of Vitamin D receptor knockout mice
Journal name Behavioural Brain Research   Check publisher's open access policy
ISSN 0166-4328
1872-7549
Publication date 2005
Sub-type Article (original research)
DOI 10.1016/j.bbr.2004.07.008
Volume 157
Issue 2
Start page 299
End page 308
Total pages 10
Editor J. P. Hudson
T. E. Robinson
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2005
Language eng
Subject C1
321204 Mental Health
320702 Central Nervous System
730211 Mental health
Abstract Vitamin D (calcitriol) is a nuclear transcription regulator acting via a nuclear hormone receptor (VDR). In addition to its role in the regulation of calcium and phosphate horneostasis and in bone formation, Vitamin D is also thought to be involved in brain function. The aim of this study was to behaviourally phenotype VDR knockout mice. We characterized the behaviour of VDR null mutant mice and wildtype littermate controls by subjecting them to a range of tests including a primary behavioural screen (using the SHIRPA protocol), rotarod, gait analysis, Y-maze, marble burying test, bedding test, holeboard test, elevated plus maze, open field test and prepulse inhibition of the acoustic startle response. There were no effects of genotype on most of the scores from the SHIRPA protocol except that VDR -/- mice had alopecia, were shorter and weighed less than VDR +/+ mice. VDR -/- mice had a shorter gait as well as impairments on the rotarod, in the bedding test and impaired habituation in both the open field and on the acoustic startle response. The VDR -/- mice had normal acoustic startle responses but had impaired PPI at long (256 ms) but not short (64 ms) prepulse to pulse intervals. The VDR -/- mice were less active in the open field and buried fewer marbles in the marble burying test. However, there were no differences in the time spent on the open arms of the elevated plus maze or in working memory as assessed by repeat arm entries on the Y-maze. Therefore, it appears that VDR -/- mice have muscular and motor impairments that significantly affects locomotor behaviour but seemingly no impairments in cognition as indicated by exploration, working memory or anxiety. (C) 2004 Elsevier B.V. All rights reserved.
Keyword acoustic startle
anxiety
behavioural phenotype
locomotor activity
mouse
sensorimotor gating
VDR
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2006 Higher Education Research Data Collection
Queensland Brain Institute Publications
ERA 2012 Admin Only
 
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Created: Wed, 15 Aug 2007, 06:26:08 EST