Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation

Banks, GB, Kanjhan, R, Wiese, S, Kneussel, M, Wong, LM, O'Sullivan, G, Sendtner, M, Bellingham, MC, Betz, H and Noakes, PG (2005) Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation. Journal of Neuroscience, 25 5: 1249-1259. doi:10.1523/JNEUROSCI.1786-04.2005

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Author Banks, GB
Kanjhan, R
Wiese, S
Kneussel, M
Wong, LM
O'Sullivan, G
Sendtner, M
Bellingham, MC
Betz, H
Noakes, PG
Title Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2005
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.1786-04.2005
Open Access Status File (Publisher version)
Volume 25
Issue 5
Start page 1249
End page 1259
Total pages 11
Editor Gary L. Westbrook
Place of publication Washington
Publisher Soc Neuroscience
Collection year 2005
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract GABAergic and glycinergic synaptic transmission is proposed to promote the maturation and refinement of the developing CNS. Here we provide morphological and functional evidence that glycinergic and GABAergic synapses control motoneuron development in a region-specific manner during programmed cell death. In gephyrin-deficient mice that lack all postsynaptic glycine receptor and some GABA(A) receptor clusters, there was increased spontaneous respiratory motor activity, reduced respiratory motoneuron survival, and decreased innervation of the diaphragm. In contrast, limb-innervating motoneurons showed decreased spontaneous activity, increased survival, and increased innervation of their target muscles. Both GABA and glycine increased limb-innervating motoneuron activity and decreased respiratory motoneuron activity in wild-type mice, but only glycine responses were abolished in gephyrin-deficient mice. Our results provide genetic evidence that the development of glycinergic and GABAergic synaptic inputs onto motoneurons plays an important role in the survival, axonal branching, and spontaneous activity of motoneurons in developing mammalian embryos.
Keyword Motor Neuron
Synapse Formation
Cell Death
Gaba
Glycine
Axon Branching
Neurosciences
Programmed Cell-death
Amyotrophic-lateral-sclerosis
Gaba(a) Receptor Subtypes
Gephyrin-deficient Mice
Tubulin Linker Protein
Embryo Spinal-cord
Neurotrophic Factor
Neuromuscular-junction
Rat Motoneurons
Chick-embryo
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 06:23:58 EST