Plant-based immunocontraceptive control of wildlife - "potentials, limitations, and possums"

Polkinghorne, I., Hamerli, D., Cowan, P. and Duckworth, J. (2005) Plant-based immunocontraceptive control of wildlife - "potentials, limitations, and possums". Vaccine, 23 15: 1847-1850. doi:10.1016/j.vaccine.2004.11.016

Author Polkinghorne, I.
Hamerli, D.
Cowan, P.
Duckworth, J.
Title Plant-based immunocontraceptive control of wildlife - "potentials, limitations, and possums"
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-410X
Publication date 2005
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2004.11.016
Volume 23
Issue 15
Start page 1847
End page 1850
Total pages 4
Place of publication Oxford
Publisher Elsevier Sci Ltd
Collection year 2005
Language eng
Subject C1
1103 Clinical Sciences
Abstract Possums (Trichosurus vulpecula), originally introduced from Australia, are spread over 90% of New Zealand and cause major economic and environmental damage. Immunocontraception has been suggested as a humane means to control them. Marsupial-specific reproductive antigens expressed at high levels in edible transgenic plant tissue might provide a safe, effective, and cheap oral delivery bait for immuno-contraceptive control. As proof of concept, female possums vaccinated with immunocontraceptive antigens showed reduced fertility, and possums fed with potato-expressed heat labile toxin-B (LT-B) had mucosal and systemic immune responses to the antigen. This demonstrated that immunocontraception was effective in possums and that oral delivery in edible plant material might be possible. Nuclear transformation with reporter genes showed that transgenic carrot roots accumulate high levels of foreign protein in edible tissues, indicating their potential as a delivery vector. However, prior to attempts at large scale production, more effective immunocontraceptive antigen-adjuvant formulations are probably required before plant-based immunocontraception can become a major tool for immunocontraceptive control of overabundant vertebrate pests. (c) 2004 Elsevier Ltd. All rights reserved.
Keyword Immunocontraception
Plant-derived Vaccines
Medicine, Research & Experimental
Veterinary Sciences
Brushtail Possum
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2006 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 06:20:22 EST