Fusing subunit antigens to interleukin-2 and encapsulating them in liposomes improves their antigenicity but not their protective efficacy

Wales, J. R., Baird, M. A., Davies, N. M. and Buchan, G. S. (2005) Fusing subunit antigens to interleukin-2 and encapsulating them in liposomes improves their antigenicity but not their protective efficacy. Vaccine, 23 17-18: 2339-2341. doi:10.1016/j.vaccine.2005.01.040


Author Wales, J. R.
Baird, M. A.
Davies, N. M.
Buchan, G. S.
Title Fusing subunit antigens to interleukin-2 and encapsulating them in liposomes improves their antigenicity but not their protective efficacy
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-410X
Publication date 2005
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2005.01.040
Volume 23
Issue 17-18
Start page 2339
End page 2341
Total pages 3
Editor J.B. Campbell
K. Yamanishi
R.E. Spier
Place of publication U.K.
Publisher Elsevier
Collection year 2005
Language eng
Subject C1
320299 Immunology not elsewhere classified
730101 Infectious diseases
11 Medical and Health Sciences
1107 Immunology
Abstract Subunit vaccines commonly lack sufficient immunogenicity to stimulate a comprehensive protective immune response in vivo. We have investigated the potential of specific cytokines (interleukin-2) and particulate delivery systems (liposomes) to enhance antigenicity. Here we report that the IgG1 and IFN-gamma responses to a subunit antigen, consisting of a T and B-cell epitope from Influenza haemagglutinin, can be improved when it is both fused to interelukin-2 and encapsulated in liposomes. However, this vaccine formulation was not able to protect animals against a challenge with live Influenza A/PR/8/34 virus. The addition of more potent immune stimulators may be necessary to improve responses. (c) 2005 Elsevier Ltd. All rights reserved.
Keyword Immunology
Medicine, Research & Experimental
Veterinary Sciences
Liposomes
Interleukin-2
Subunit Influenza Vaccines
Macrophage
Mice
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Pharmacy Publications
 
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Created: Wed, 15 Aug 2007, 06:19:44 EST