Developmental Vitamin D-3 deficiency alters the adult rat brain

Feron, F, Burne, THJ, Brown, J, Smith, E, McGrath, JJ, Mackay-Sim, A and Eyles, DW (2005) Developmental Vitamin D-3 deficiency alters the adult rat brain. Brain Research Bulletin, 65 2: 141-148. doi:10.1016/j.brainresbull.2004.12.007

Author Feron, F
Burne, THJ
Brown, J
Smith, E
McGrath, JJ
Mackay-Sim, A
Eyles, DW
Title Developmental Vitamin D-3 deficiency alters the adult rat brain
Journal name Brain Research Bulletin   Check publisher's open access policy
ISSN 0361-9230
Publication date 2005
Sub-type Article (original research)
DOI 10.1016/j.brainresbull.2004.12.007
Volume 65
Issue 2
Start page 141
End page 148
Total pages 8
Editor S. Dunnett
Place of publication Oxford, United Kingdom
Publisher Pergamon-Elsevier Science
Collection year 2005
Language eng
Subject 321021 Psychiatry
730211 Mental health
Abstract There is growing evidence that Vitamin D-3 (1,25-dihydroxyvitamin D-3) is involved in brain development. We have recently shown that the brains of newborn rats from Vitamin D-3 deficient dams were larger than controls, had increased cell proliferation, larger lateral ventricles, and reduced cortical thickness. Brains from these animals also had reduced expression of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor. The aim of the current study was to examine if there were any permanent outcomes into adulthood when the offspring of Vitamin D-3 deficient dams were restored to a normal diet. The brains of adult rats were examined at 10 weeks of age after Vitamin D-3 deficiency until birth or weaning. Compared to controls animals that were exposed to transient early Vitamin D-3 deficiency had larger lateral ventricles, reduced NGF protein content, and reduced expression of a number genes involved in neuronal structure, i.e. neurofilament or MAP-2 or neurotransmission, i.e. GABA-(alpha 4). We conclude that transient early life hypovitaminosis D-3 not only disrupts brain development but leads to persistent changes in the adult brain. In light of the high incidence of hypovitammosis D-3 in women of child-bearing age, the public health implications of these findings warrant attention. (c) 2005 Elsevier Inc. All rights reserved.
Keyword Brain Development
Brain Morphology
Nerve Growth-factor
1,25-dihydroxyvitamin D-3
Neurotrophic Factor
Nuclear Receptors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2006 Higher Education Research Data Collection
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 136 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 156 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 06:19:36 EST