Expression of human neuronal protein 22, a novel cytoskeleton-associated protein, was decreased in the anterior cingulate cortex of schizophrenia

Ito, Masayuki, Depaz, Iris, Wilce, Peter, Suzuki, Toshimitsu, Niwa, Shin-ichi and Matsumoto, Izuru (2005) Expression of human neuronal protein 22, a novel cytoskeleton-associated protein, was decreased in the anterior cingulate cortex of schizophrenia. Neuroscience Letters, 378 3: 125-130. doi:10.1016/j.neulet.2004.12.079


Author Ito, Masayuki
Depaz, Iris
Wilce, Peter
Suzuki, Toshimitsu
Niwa, Shin-ichi
Matsumoto, Izuru
Title Expression of human neuronal protein 22, a novel cytoskeleton-associated protein, was decreased in the anterior cingulate cortex of schizophrenia
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
1872-7972
Publication date 2005
Sub-type Article (original research)
DOI 10.1016/j.neulet.2004.12.079
Volume 378
Issue 3
Start page 125
End page 130
Total pages 6
Place of publication Shannon, Co. Clare Ireland
Publisher Elsevier
Collection year 2005
Language eng
Subject 270107 Cell Neurochemistry
730104 Nervous system and disorders
Abstract Human neuronal protein 22 (hNP22) is a novel neuron-specific protein featuring numerous motifs previously described in cytoskeleton-associating and signaling proteins. Because previous studies have supported abnormalities in neuronal cytoarchitecture and/or development in the schizophrenia brain, we examined the expression of hNP22 in the anterior cingulate cortex, the hippocampus and the prefrontal cortex of schizophrenic and normal control postmortem brains using high-sensitive immunohistochemistry. Seven schizophrenic and seven age- and sex-matched control brains were examined. The ratio of hNP22-immunopositive cells/total cells was significantly reduced in layer V (p = .020) and layer VI (p = .022) of the anterior cingulate cortex of schizophrenic brain compared with controls. In contrast, there were no significant changes observed in the hippocampus and the prefrontal cortex. These results suggest that altered expression of hNP22 may be associated with modifications in neuronal cytoarchitecture leading to dysregulation of neural signal transduction in the anterior cingulate cortex of the schizophrenia brain.
Keyword Schizophrenia
Human Neuronal Protein
Immunchistochemistry
Postmortem Human Brain
Cytoskeleton
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 17 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 06:17:59 EST