BOC, brother of CDO, is a dorsoventral axon-guidance molecule in the embryonic vertebrate brain

Connor, Robin M., Allen, Chelsea L., Devine, Christine A., Claxton, Christina and Key, Brian (2005) BOC, brother of CDO, is a dorsoventral axon-guidance molecule in the embryonic vertebrate brain. Journal Of Comparative Neurology, 485 1: 32-42. doi:10.1002/cne.20503

Author Connor, Robin M.
Allen, Chelsea L.
Devine, Christine A.
Claxton, Christina
Key, Brian
Title BOC, brother of CDO, is a dorsoventral axon-guidance molecule in the embryonic vertebrate brain
Journal name Journal Of Comparative Neurology   Check publisher's open access policy
ISSN 0021-9967
Publication date 2005-04-25
Sub-type Article (original research)
DOI 10.1002/cne.20503
Volume 485
Issue 1
Start page 32
End page 42
Total pages 11
Editor C. Saper
Place of publication New York
Publisher Wiley-Liss
Collection year 2005
Language eng
Subject C1
730104 Nervous system and disorders
270502 Neurobiology
Abstract The early axon scaffolding in the embryonic vertebrate brain consists of a series of ventrally projecting axon tracts that grow into a single major longitudinal pathway connected across the midline by commissures. We have investigated the role of Brother of CDO (BOC), an immunoglobulin (Ig) superfamily member distantly related to the Roundabout (Robo) family of axon-guidance receptors, in the development of this embryonic template of axon tracts in the zebrafish brain. A zebrafish homologue of BOC was isolated and shown to be expressed predominantly in the developing neural plate and later in the neural tube and developing brain. Zebrafish boc was initially highly localized to discrete bands in the mid- and hindbrain, but, as the major brain subdivisions emerged, it became more evenly expressed along the rostrocaudal axis, particularly in dorsal regions. The function of zebrafish boc was examined by a loss-of-function approach. Analysis of embryos injected with antisense morpholinos designed against boc revealed highly selective defects in the development of dorsoventrally projecting axon tracts. Loss of boc caused ventrally projecting axons, particularly those arising from the presumptive telencephalon, to follow aberrant trajectories. These data indicate that boc is an axon-guidance molecule playing a fundamental role in pathfinding during the early patterning of the axon scaffold in the embryonic vertebrate brain. (c) 2005 Wiley-Liss, Inc.
Keyword chemorepulsion
growth cone
Midbrain-hindbrain Boundary
Zebrafish Brain
Myogenic Differentiation
Robo Receptors
Growth Cones
Q-Index Code C1
Additional Notes DOI: 10.1002/cne.20503

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Created: Wed, 15 Aug 2007, 06:15:43 EST