Plasma renin and aldosterone measurements in low renin hypertensive states

Sealey, JE, Gordon, RD and Mantero, F (2005) Plasma renin and aldosterone measurements in low renin hypertensive states. Trends In Endocrinology And Metabolism, 16 3: 86-91. doi:10.1016/j.tem.2005.02.006

Author Sealey, JE
Gordon, RD
Mantero, F
Title Plasma renin and aldosterone measurements in low renin hypertensive states
Journal name Trends In Endocrinology And Metabolism   Check publisher's open access policy
ISSN 1043-2760
Publication date 2005
Sub-type Editorial
DOI 10.1016/j.tem.2005.02.006
Volume 16
Issue 3
Start page 86
End page 91
Total pages 6
Editor K. J. Catt
Place of publication UK
Publisher Elsevier Ltd, Trends Journals
Collection year 2005
Language eng
Subject C1
321004 Endocrinology
730105 Endocrine organs and diseases (incl. diabetes)
Abstract Plasma renin concentrations are extremely low, requiring high sensitivity methods to detect low renin hypertensive states. Moreover, plasma prorenin must not cryoactivate to renin to avoid falsely high values. The enzyme kinetic plasma renin activity (PRA) test has the required sensitivity, whereas direct renin assays and PRA tests with short incubation times are usually not accurate enough. Test specificity is essential for plasma aldosterone. The Nichols Advantage aldosterone assay is fast and automated but requires great attention to quality control. Here, the impact of renin on the aldosterone:renin ratio as a screening test for primary aldosteronism is reviewed. A sensitive plasma renin test is essential for the diagnosis of low renin hypertensive states and, currently, can be consistently achieved only with the PRA radioimmunoassay.
Keyword Endocrinology & Metabolism
Active Renin
Q-Index Code C1

Document type: Journal Article
Sub-type: Editorial
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
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Citation counts: TR Web of Science Citation Count  Cited 55 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 65 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 06:14:57 EST