Echinacea intake induces an immune response through altered expression of leucocyte hsp70, increased white cell counts and improved erythrocyte antioxidant defences

Agnew, LL, Guffogg, SP, Matthias, A, Lehmann, RP, Bone, KM and Watson, K (2005) Echinacea intake induces an immune response through altered expression of leucocyte hsp70, increased white cell counts and improved erythrocyte antioxidant defences. Journal of Clinical Pharmacy And Therapeutics, 30 4: 363-369. doi:10.1111/j.1365-2710.2005.00658.x


Author Agnew, LL
Guffogg, SP
Matthias, A
Lehmann, RP
Bone, KM
Watson, K
Title Echinacea intake induces an immune response through altered expression of leucocyte hsp70, increased white cell counts and improved erythrocyte antioxidant defences
Journal name Journal of Clinical Pharmacy And Therapeutics   Check publisher's open access policy
ISSN 0269-4727
Publication date 2005
Sub-type Article (original research)
DOI 10.1111/j.1365-2710.2005.00658.x
Volume 30
Issue 4
Start page 363
End page 369
Total pages 7
Place of publication Oxford
Publisher Blackwell Publishing
Collection year 2005
Language eng
Subject C1
Abstract Objective: To study the effect of Echinacea tablets on the expression of leucocyte heat shock protein 70 (hsp70), erythrocyte haemolysis, plasma antioxidant status, serum chemistry, haematological values and plasma alkylamide concentrations. Method: Eleven healthy individuals (26-61 years of age) were evaluated at baseline (day 1) and on day 15 after consuming two commercially blended Echinacea tablets daily for 14 days. Results: Echinacea supplementation enhanced the fold increase in leucocyte hsp70 expression after a mild heat shock (P=0.029). White cell counts (WCC) were also increased (P=0.043). We also observed a preventative effect against free radical induced erythrocyte haemolysis (P=0.006) indicative of an antioxidant effect. Conclusion: The pilot study suggests that Echinacea may invoke an immune response through altered expression of hsp70 and increased WCC.
Keyword Antioxidant
Echinacea
Heat Shock Protein 70
Immunomodulation
Pharmacology & Pharmacy
Heat-shock Proteins
Innate
Macrophages
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2006 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
 
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 06:05:59 EST