Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism

Larsen, Jill Everland, Colosimo, Maree Louise, Yang, Ian Anthony, Bowman, Rayleen, Zimmerman, Paul Victor and Fong, Kwun Meng (2005) Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism. Cancer Causes and Control, 16 5: 579-585. doi:10.1007/s10552-004-7842-3


Author Larsen, Jill Everland
Colosimo, Maree Louise
Yang, Ian Anthony
Bowman, Rayleen
Zimmerman, Paul Victor
Fong, Kwun Meng
Title Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism
Journal name Cancer Causes and Control   Check publisher's open access policy
ISSN 0957-5243
1573-7225
Publication date 2005-06
Sub-type Article (original research)
DOI 10.1007/s10552-004-7842-3
Volume 16
Issue 5
Start page 579
End page 585
Total pages 7
Place of publication Dordrecht; Netherlands
Publisher Springer
Collection year 2005
Language eng
Subject C1
Abstract Objective: The Ile462Val substitution in the cytochrome P450 1A1 gene (CYP1A1) results in increased enzymatic activity. Preliminary data suggesting a link between this polymorphism and lung cancer risk in Caucasians are inconsistent, reflecting small sample sizes and the relatively low frequency of the variant. Methods: The data set consisted of 1050 primary non-small cell lung cancer cases and 581 controls, a large homogenous population designed specifically to address previous inconsistencies. Patients were genotyped using a PCR-RFLP technique. Results: Carriers of the valine allele, CYP1A1*2C, (Ile/Val or Val/Val genotypes) were significantly over-represented in non-small cell lung cancer compared to controls (OR=1.9; 95% CI=1.2-2.9; p=0.005) when adjusted for confounders, particularly in women (OR=4.6; 95% CI=1.7-12.4; p=0.003). The valine variant was statistically significantly over-represented in cases of lung cancer younger than the median age (64 years) (OR=2.5; 95% CI=1.3-4.8; p=0.005) and cases with less than the median cumulative tobacco-smoke exposure (46 pack-years) (OR=2.4; 95% CI=1.3-4.7; p=0.007). Conclusions: These new data establish an association between the CYP1A1 Ile462Val polymorphism and the risk of developing non-small cell lung cancer, especially among women.
Keyword Cytochrome P450cyp1a1
Carcinoma
Non-small-cell Lung
Polymorphism (genetics)
Genetic Predisposition To Disease
Oncology
Public, Environmental & Occupational Health
Genetic Polymorphisms
Cyp1a1 Polymorphisms
Cigarette-smoking
Pooled Analysis
United-states
Exon 7
Susceptibility
Adenocarcinoma
Association
Population
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 06:03:26 EST