Systemic regulation of intestinal iron absorption

Steele, Teresa M., Frazer, David M. and Anderson, Gregory J. (2005) Systemic regulation of intestinal iron absorption. Iubmb Life, 57 7: 499-503. doi:10.1080/15216540500149904


Author Steele, Teresa M.
Frazer, David M.
Anderson, Gregory J.
Title Systemic regulation of intestinal iron absorption
Journal name Iubmb Life   Check publisher's open access policy
ISSN 1521-6543
1521-6551
Publication date 2005-10
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1080/15216540500149904
Volume 57
Issue 7
Start page 499
End page 503
Total pages 5
Editor A. Azzi
W. J. Whelan
Place of publication London, England
Publisher Taylor & Francis
Collection year 2005
Language eng
Subject C1
321006 Gastroenterology and Hepatology
730113 Digestive system and disorders
Abstract The intestinal absorption of the essential trace element iron and its mobilization from storage sites in the body are controlled by systemic signals that reflect tissue iron requirements. Recent advances have indicated that the liver-derived peptide hepcidin plays a central role in this process by repressing iron release from intestinal enterocytes, macrophages and other body cells. When iron requirements are increased, hepcidin levels decline and more iron enters the plasma. It has been proposed that the level of circulating diferric transferrin, which reflects tissue iron levels, acts as a signal to alter hepcidin expression. In the liver, the proteins HFE, transferrin receptor 2 and hemojuvelin may be involved in mediating this signal as disruption of each of these molecules decreases hepcidin expression. Patients carrying mutations in these molecules or in hepcidin itself develop systemic iron loading (or hemochromatosis) due to their inability to down regulate iron absorption. Hepcidin is also responsible for the decreased plasma iron or hypoferremia that accompanies inflammation and various chronic diseases as its expression is stimulated by pro-inflammatory cytokines such as interleukin 6. The mechanisms underlying the regulation of hepcidin expression and how it acts on cells to control iron release are key areas of ongoing research.
Keyword Iron
Iron Absorption
Hepcidin
Transferring
Transferrin Receptor
Hfe
Hemojuvelin
Biochemistry & Molecular Biology
Cell Biology
Antimicrobial Peptide Hepcidin
Juvenile Hemochromatosis
Expression
Overload
Liver
Gene
Inflammation
Mutations
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2006 Higher Education Research Data Collection
ERA 2012 Admin Only
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 06:00:45 EST