Pressure support ventilation with the ProSeal (R) laryngeal mask airway. A comparison of sevoflurane, isoflurane and propofol

Keller, C., Brimacombe, J., Hoermann, C., Loeckinger, A. and Kleinsasser, A. (2005) Pressure support ventilation with the ProSeal (R) laryngeal mask airway. A comparison of sevoflurane, isoflurane and propofol. European Journal of Anaesthesiology, 22 8: 630-633. doi:10.1017/S0265021505001055


Author Keller, C.
Brimacombe, J.
Hoermann, C.
Loeckinger, A.
Kleinsasser, A.
Title Pressure support ventilation with the ProSeal (R) laryngeal mask airway. A comparison of sevoflurane, isoflurane and propofol
Journal name European Journal of Anaesthesiology   Check publisher's open access policy
ISSN 0265-0215
Publication date 2005
Sub-type Article (original research)
DOI 10.1017/S0265021505001055
Volume 22
Issue 8
Start page 630
End page 633
Total pages 4
Place of publication New York
Publisher Cambridge University Press
Collection year 2005
Language eng
Subject C1
110301 Anaesthesiology
Abstract Background and objective: There are no data about the influence of anaesthetics on cardiovascular variables during pressure support ventilation of the lungs through the laryngeal mask airway. We compared propofol, sevoflurane and isoflurane for maintenance of anaesthesia with the ProSeal (R) laryngeal mask airway during pressure support ventilation. Methods: Sixty healthy adults undergoing peripheral musculo-skeletal surgery were randomized for maintenance with sevoflurane end-tidal 29%, isoflurane end-tidal 1.1% or propofol 6 mg kg(-1) h(-1) in oxygen 33% and air. Pressure support ventilation comprised positive end-expiratory pressure set at 5 cmH(2)O, and pressure support set 5 cmH(2)O above positive end-expiratory pressure. Pressure support was initiated when inspiration produced a 2 cmH(2)O reduction in airway pressure. A blinded observer recorded cardiorespiratory variables (heart rate, mean blood pressure, oxygen saturation, air-way occlusion pressure, respiratory rate, expired tidal volume, expired minute volume and end-tidal CO2), adverse events and emergence times. Results: Respiratory rate and minute volume were 10-21% lower, and end-tidal CO2 6-11% higher with the propofol group compared with the sevoflurane or isoflurane groups, but otherwise cardiorespiratory variables were similar among groups. No adverse events occurred in any group. Emergence times were longer with the propofol group compared with the sevoflurane or isoflurane groups (10 vs. 7 vs. 7 min). Conclusion: Lung ventilation is less effective and emergence times are longer with propofol than sevoflurane or isoflurane for maintenance of anaesthesia during pressure support ventilation with the ProSeal (R) laryngeal mask airway. However, these differences are small and of doubtful clinical importance.
Keyword Intubation
Intratracheal
Laryngeal Masks
Pulmonary Ventilation
Respiration
Artificial
Pressure Support Ventilation
Ventilators
Mechanical
Anesthesiology
Intubation, Intratracheal, Laryngeal Masks
Respiration, Artificial
Ventilators, Mechanical
Positive-pressure
Adult Patients
Anesthesia
Insertion
Tube
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2006 Higher Education Research Data Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 05:58:50 EST