Antisense transcription in the mammalian transcriptome

RIKEN GER Group,, Wells, C. A., Frith, M., Ravasi, T., Pang, K. C., Hallinan, J. S., Mattick, J. S., Hume, D. A., Katayama, S., Tomaru, Y., Kasukawa, T., Waki, K., Nakanishi, M., Nakamura, M. and Nishida, H. (2005) Antisense transcription in the mammalian transcriptome. Science, 309 5740: 1564-1566. doi:10.1126/science.1112009

Author RIKEN GER Group,
Wells, C. A.
Frith, M.
Ravasi, T.
Pang, K. C.
Hallinan, J. S.
Mattick, J. S.
Hume, D. A.
Katayama, S.
Tomaru, Y.
Kasukawa, T.
Waki, K.
Nakanishi, M.
Nakamura, M.
Nishida, H.
Title Antisense transcription in the mammalian transcriptome
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
Publication date 2005
Sub-type Article (original research)
DOI 10.1126/science.1112009
Volume 309
Issue 5740
Start page 1564
End page 1566
Total pages 3
Place of publication Washington
Publisher American Association for the Advancement of Science
Collection year 2005
Language eng
Subject C1
270201 Gene Expression
780106 Political science and public policy
Abstract Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense transcripts (RNA interference), as well as gene silencing at the chromatin level. Global transcriptome analysis provides evidence that a large proportion of the genome can produce transcripts from both strands, and that antisense transcripts commonly link neighboring genes in complex loci into chains of linked transcriptional units. Expression profiling reveals frequent concordant regulation of sense/antisense pairs. We present experimental evidence that perturbation of an antisense RNA can alter the expression of sense messenger RNAs, suggesting that antisense transcription contributes to control of transcriptional outputs in mammals.
Keyword Biochemistry & Molecular Biology
Imprinted Genes
Noncoding Rnas
Human Genome
Q-Index Code C1
Additional Notes Authors of this document: Katayama, S; Tomaru, Y; Kasukawa, T; Waki, K; Nakanishi, M; Nakamura, M; Nishida, H; Yap, CC; Suzuki, M; Kawai, J; Suzuki, H; Carninci, P; Hayashizaki, Y; Wells, C; Frith, M; Ravasi, T; Pang, KC; Hallinan, J; Mattick, J; Hume, DA; Lipovich, L; Batalov, S; Engstrom, PG; Mizuno, Y; Faghihi, MA; Sandelin, A; Chalk, AM; Mottagui-Tabar, S; Liang, Z; Lenhard, B; Wahlestedt, C; RIKEN Genome Network Project Core; Genome Sci Grp; FANTOM Consortium. DOI: 10.1126/science.1112009

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Created: Wed, 15 Aug 2007, 05:56:32 EST