Cyclosporine A-induced changes to erythrocyte redox balance is time course-dependent

Lexis, L. A., Richards, R. S., Fassett, R. G. and Coombes, J. S. (2005) Cyclosporine A-induced changes to erythrocyte redox balance is time course-dependent. Basic & Clinical Pharmacology & Toxicology, 97 3: 135-140. doi:10.1111/j.1742-7843.2005.pto_973120.x

Author Lexis, L. A.
Richards, R. S.
Fassett, R. G.
Coombes, J. S.
Title Cyclosporine A-induced changes to erythrocyte redox balance is time course-dependent
Journal name Basic & Clinical Pharmacology & Toxicology   Check publisher's open access policy
ISSN 1742-7835
Publication date 2005
Sub-type Article (original research)
DOI 10.1111/j.1742-7843.2005.pto_973120.x
Volume 97
Issue 3
Start page 135
End page 140
Total pages 6
Editor K. Broesen
G.H. Mouret
Place of publication Oxford, UK
Publisher Blackwell Publishing
Collection year 2005
Language eng
Subject C1
321003 Cardiology (incl. Cardiovascular Diseases)
730106 Cardiovascular system and diseases
Abstract Cyclosporine A-treated transplant recipients develop pronounced cardiovascular disease and have increased oxidative stress and altered antioxidant capacity in erythrocytes and plasma. These experiments investigated the time-course of cyclosporine A-induced changes to redox balance in plasma and erythrocytes. Rats were randomly assigned to either a control or cyclosporine A-treated group. Treatment animals received 25 mg/kg of cyclosporine A via intraperitoneal injection for either 7 days or a single dose. Control rats were injected with the same volume of the vehicle. Three hours after the final injections, plasma was analysed for total antioxidant status, a-tocopherol, malondialdehyde, and creatinine. Erythrocytes were analysed for reduced glutathione (GSH), alpha-tocopherol, methaemoglobin, malondialdehyde, and the activities of superoxide dismutase, catalase, GSH peroxidase, and glucose-6-phosphate dehydrogenase (G6PD). Cyclosporine A administration for 7 days resulted in a significant increase (P < 0.05) in plasma malondialdehyde, methaemoglobin, and superoxide dismutase and catalase activities. There was a significant decrease (P < 0.05) in erythrocyte GSH concentration and G6PD activity in cyclosporine A animals. There were no significant differences (P > 0.05) between groups following a single dose of cyclosporine A in any of the measures. In summary, cyclosporine A alters erythrocyte redox balance after 7 days administration, but not after a single dose.
Keyword Pharmacology & Pharmacy
Glutathione-peroxidase Activity
Oxygen Free-radicals
Transplant Recipients
Oxidative Stress
Antioxidant Status
Chronic Rejection
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Created: Wed, 15 Aug 2007, 05:55:53 EST