Role of smoking in global and regional cancer epidemiology: current patterns and data needs

Ezzati, Majid, Henley, S. Jane, Lopez, Alan D. and Thun, Michael J. (2005) Role of smoking in global and regional cancer epidemiology: current patterns and data needs. International Journal of Cancer, 116 6: 963-971. doi:10.1002/ijc.21100

Author Ezzati, Majid
Henley, S. Jane
Lopez, Alan D.
Thun, Michael J.
Title Role of smoking in global and regional cancer epidemiology: current patterns and data needs
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 0020-7136
Publication date 2005
Sub-type Article (original research)
DOI 10.1002/ijc.21100
Volume 116
Issue 6
Start page 963
End page 971
Total pages 9
Editor S.A. Aaronson
Place of publication New York, N.Y. U.S.A.
Publisher Wiley-Liss
Collection year 2005
Language eng
Subject C1
321202 Epidemiology
730219 Behaviour and health
1103 Clinical Sciences
Abstract Although smoking is widely recognized as a major cause of cancer, there is little information on how it contributes to the global and regional burden of cancers in combination with other risk factors that affect background cancer mortality patterns. We used data from the American Cancer Society's Cancer Prevention Study II (CPS-II) and the WHO and IARC cancer mortality databases to estimate deaths from 8 clusters of site-specific cancers caused by smoking, for 14 epidemiologic subregions of the world, by age and sex. We used lung cancer mortality as an indirect marker for accumulated smoking hazard. CPS-II hazards were adjusted for important covariates. In the year 2000, an estimated 1.42 (95% CI 1.27-1.57) million cancer deaths in the world, 21% of total global cancer deaths, were caused by smoking. Of these, 1.18 million deaths were among men and 0.24 million among women; 625,000 (95% CI 485,000-749,000) smoking-caused cancer deaths occurred in the developing world and 794,000 (95% CI 749,000-840,000) in industrialized regions. Lung cancer accounted for 60% of smoking-attributable cancer mortality, followed by cancers of the upper aerodigestive tract (20%). Based on available data, more than one in every 5 cancer deaths in the world in the year 2000 were caused by smoking, making it possibly the single largest preventable cause of cancer mortality. There was significant variability across regions in the role of smoking as a cause of the different site-specific cancers. This variability illustrates the importance of coupling research and surveillance of smoking with that for other risk factors for more effective cancer prevention. (C) 2005 Wiley-Liss, Inc.
Keyword Smoking
Cancer Mortality
Cause Of Death
Risk Assessment
Lung Cancer
Major Risk-factors
Q-Index Code C1

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 116 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 140 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 05:55:47 EST