Wrapping things up about virus RNA replication

Mackenzie, Jason (2005) Wrapping things up about virus RNA replication. Traffic, 6 11: 967-977.


Author Mackenzie, Jason
Title Wrapping things up about virus RNA replication
Journal name Traffic   Check publisher's open access policy
ISSN 1398-9219
Publication date 2005
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1600-0854.2005.00339.x
Volume 6
Issue 11
Start page 967
End page 977
Total pages 11
Place of publication Oxford
Publisher Blackwell Publishing
Collection year 2005
Language eng
Subject C1
270303 Virology
780105 Biological sciences
1601 Anthropology
1701 Psychology
Abstract All single-stranded 'positive-sense' RNA viruses that infect mammalian, insect or plant cells rearrange internal cellular membranes to provide an environment facilitating virus replication. A striking feature of these unique membrane structures is the induction of 70-100 nm vesicles (either free within the cytoplasm, associated with other induced vesicles or bound within a surrounding membrane) harbouring the viral replication complex (RC). Although similar in appearance, the cellular composition of these vesicles appears to vary for different viruses, implying different organelle origins for the intracellular sites of viral RNA replication. Genetic analysis has revealed that induction of these membrane structures can be attributed to a particular viral gene product, usually a non-structural protein. This review will highlight our current knowledge of the formation and composition of virus RCs and describe some of the similarities and differences in RNA-membrane interactions observed between the virus families Flaviviridae and Picornaviridae.
Keyword Cellular Ultrastructure
Membrane Rearrangements
Virus-host Interactions
Virus Rna Replication
Cell Biology
Mouse Hepatitis-virus
Double-stranded-rna
Intracellular Membrane Rearrangements
Flavivirus-infected Cells
Poliovirus Proteins 2b
In-situ Hybridization
Full-length Cdna
Kunjin Virus
Endoplasmic-reticulum
Viral Replication
Q-Index Code C1
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
 
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