Functionalized organosilica microspheres via a novel emulsion-based route

Miller, CR, Vogel, R, Surawski, PPT, Jack, KS, Corrie, SR and Trau, M (2005) Functionalized organosilica microspheres via a novel emulsion-based route. Langmuir, 21 21: 9733-9740. doi:10.1021/la0514112

Author Miller, CR
Vogel, R
Surawski, PPT
Jack, KS
Corrie, SR
Trau, M
Title Functionalized organosilica microspheres via a novel emulsion-based route
Journal name Langmuir   Check publisher's open access policy
ISSN 0743-7463
Publication date 2005-10-11
Sub-type Article (original research)
DOI 10.1021/la0514112
Volume 21
Issue 21
Start page 9733
End page 9740
Total pages 8
Place of publication Washington, DC, U.S.A.
Publisher American Chemical Society
Collection year 2005
Language eng
Subject C1
250103 Colloid and Surface Chemistry
730305 Diagnostic methods
Formatted abstract
Thiol-functionalized organosilica microspheres were synthesized via a two-step process: (1) acid-catalyzed hydrolysis and condensation of 3-mercaptopropyltrimethoxysilane (MPTMS), followed by (2) base-catalyzed condensation, which led to the rapid formation of emulsion droplets with a narrow size distribution. These droplets continued to condense to form solid microspheres. Solution 29Si NMR and optical microscopy were applied to study the mechanism of this novel synthetic route. Solid-state 29Si NMR, SEM, zeta potential titration, and Coulter counter measurements were used to study the bulk and surface properties and to determine the particle size distributions of the final microspheres. Compared to conventional Stöber silica particles, these microspheres were shown to have a lower degree of cross-linking (average degree of condensation, r = 1.25), a larger average size (up to 6 μm), and a higher isoelectric point (pH = 4.4). Confocal microscopy of dye-labeled microspheres showed an even distribution of dye molecules throughout the interior, characteristic of a readily accessible and permeable organosilica network. These findings have implications for the production of functionalized solid supports for use in catalysis and biological applications, such as optically encoded carriers for combinatorial synthesis.
© 2005 American Chemical Society
Keyword Chemistry, Physical
Monodisperse Silica Spheres
Controlled Growth
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Created: Wed, 15 Aug 2007, 05:52:38 EST