 |
Accurate prediction of scorpion toxin functional properties from primary structures
Tan, PTJ, Srinivasan, KN, Seah, SH, Koh, JLY, Tan, TW, Ranganathan, S and Brusic, V (2005) Accurate prediction of scorpion toxin functional properties from primary structures. Journal of Molecular Graphics & Modelling, 24 : 17-24.
|
|
|
| Author(s) |
Tan, PTJ
Srinivasan, KN
Seah, SH
Koh, JLY
Tan, TW
Ranganathan, S
Brusic, V
|
| Title |
Accurate prediction of scorpion toxin functional properties from primary structures
|
| Journal name |
Journal of Molecular Graphics & Modelling
|
| Publication date |
2005
|
| Volume number |
24
|
| ISBN |
1093-3263
|
| Start page |
17
|
| End page |
24
|
| Total pages |
8
|
| Place of publication |
New York
|
| Publisher |
Elsevier Science Inc
|
| Collection year |
2005
|
| Subject |
C1
250699 Theoretical and Computational Chemistry not elsewhere classified
780105 Biological sciences
|
| Abstract |
Scorpion toxins are common experimental tools for studies of biochemical and pharmacological properties of ion channels. The number of functionally annotated scorpion toxins is steadily growing, but the number of identified toxin sequences is increasing at much faster pace. With an estimated 100,000 different variants, bioinformatic analysis of scorpion toxins is becoming a necessary tool for their systematic functional analysis. Here, we report a bioinformatics-driven system involving scorpion toxin structural classification, functional annotation, database technology, sequence comparison, nearest neighbour analysis, and decision rules which produces highly accurate predictions of scorpion toxin functional properties. (c) 2005 Elsevier Inc. All rights reserved.
|
| Keyword(s) |
Prediction Systems
Protein Function
Protein Classification
Structure-function Relationship
Biochemical Research Methods
Biochemistry & Molecular Biology
Computer Science, Interdisciplinary Applications
Crystallography
Gated Sodium-channels
K+ Channels
Rat-brain
Mesobuthus-tamulus
Chloride Channels
Tityus-bahiensis
Buthus-martensi
Venom
Potassium
Peptides
|
|
|
