Exercise and the endothelial cell

Marsh, Susan A. and Coombes, Jeff S. (2005) Exercise and the endothelial cell. International Journal of Cardiology, 99 2: 165-169. doi:10.1016/j.ijcard.2004.02.005

Author Marsh, Susan A.
Coombes, Jeff S.
Title Exercise and the endothelial cell
Journal name International Journal of Cardiology   Check publisher's open access policy
ISSN 0167-5273
Publication date 2005
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.ijcard.2004.02.005
Volume 99
Issue 2
Start page 165
End page 169
Total pages 5
Editor C. Kawai
A. J. S. Coats
Place of publication Clare
Publisher Elsevier Science Ireland Ltd
Collection year 2005
Language eng
Subject C1
321003 Cardiology (incl. Cardiovascular Diseases)
321401 Exercise Physiology
730106 Cardiovascular system and diseases
Abstract Regular exercise is known to be effective in the prevention and treatment of cardiovascular disease. Among the cardioprotectant mechanisms influenced by exercise, the endothelium is becoming recognised as a major target. Preservation of endothelial cell structure is vital for frictionless blood flow, prevention of macrophage and lipid infiltration and, ultimately, optimal vascular function. Exercise causes various kinds of mechanical, chemical and thermal stresses, and repeated exposure to these stresses may precondition the endothelial cell to future stresses through a number of different mechanisms. This review discusses stress-induced changes in endothelial cell morphology, biochemistry and components of platelet activation and cell adhesion that impact on endothelial cell structure. An enhanced understanding of the effects of exercise on the endothelial cell will assist in directing future research into the prevention of cardiovascular disease. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
Keyword Exercise
Oxidative Stress
Fluid Shear-stress
Nitric-oxide Synthase
Short-term Exercise
Prostacyclin Production
Platelet Activation
Adhesion Molecules
Modulates Expression
Cardiac & Cardiovascular Systems
Q-Index Code C1
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Human Movement and Nutrition Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 32 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 05:49:05 EST