The effects of pre-weaning undernutrition on the expression levels of free radical deactivating enzymes in the mouse brain

Partadireda, G., Simpson, R. and Bedi, K. S. (2005) The effects of pre-weaning undernutrition on the expression levels of free radical deactivating enzymes in the mouse brain. Nutritional Neuroscience, 8 3: 183-193. doi:10.1080/10284150500133037


Author Partadireda, G.
Simpson, R.
Bedi, K. S.
Title The effects of pre-weaning undernutrition on the expression levels of free radical deactivating enzymes in the mouse brain
Journal name Nutritional Neuroscience   Check publisher's open access policy
ISSN 1476-8305
1028-415X
Publication date 2005
Sub-type Article (original research)
DOI 10.1080/10284150500133037
Volume 8
Issue 3
Start page 183
End page 193
Total pages 11
Place of publication United Kingdom
Publisher Maney Publishing
Collection year 2005
Language eng
Subject C1
1109 Neurosciences
Abstract A mild degree of undernutrition brought about by restricting the amount of food in the diet is known to alter the life span of an animal. It has been hypothesised that this may be related to the effects of undernutrition on an animals anti-oxidant defense system. We have therefore, used real-time PCR (rt-PCR) techniques to determine the levels of mRNA expression for manganese superoxide dismutase (MnSOD), copper/zinc superoxide dismutase (Cu/ZnSOD), glutathione peroxidase 1 (GPx 1) and catalase in the brains of Quackenbush mice undernourished from conception until 21-post-natal days of age. It was found that 21- and 61-day-old undernourished mice had a deficit in the expression of Cu/ZnSOD in both the cerebellum and forebrain regions compared to age-matched controls. The expression of MnSOD was found to be greater in the cerebellum, but not the forebrain region, of 21-day-old undernourished mice. There were no significant differences in the expression of GPx 1 and catalase between control and undernourished or previously undernourished mice. Our results confirm that undernutrition during the early life of a mouse may disrupt some of the enzymes involved in the anti-oxidant defense systems.
Keyword Diet Restriction
Ros Enzymes
Mnsod
Cu/zn Sod
Glutathione Peroxidase
Catalase
Rt-pcr
Neurosciences
Nutrition & Dietetics
Transgenic Drosophila-melanogaster
Containing Superoxide-dismutase
Early-life Undernutrition
Dietary Restriction
Caloric Restriction
Oxidative Stress
Antioxidant Enzymes
Food Restriction
Adult-rats
Lipid-peroxidation
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 05:48:38 EST