Clathrin-independent endocytosis: New insights into caveolae and non-caveolar lipid raft carriers

Kirkham, Matthew and Parton, Robert G. (2005) Clathrin-independent endocytosis: New insights into caveolae and non-caveolar lipid raft carriers. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1745 3: 273-286. doi:10.1016/j.bbamcr.2005.06.002


Author Kirkham, Matthew
Parton, Robert G.
Title Clathrin-independent endocytosis: New insights into caveolae and non-caveolar lipid raft carriers
Journal name Biochimica et Biophysica Acta (BBA) - Molecular Cell Research   Check publisher's open access policy
ISSN 0167-4889
Publication date 2005-09-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.bbamcr.2005.06.002
Volume 1745
Issue 3
Start page 273
End page 286
Total pages 14
Place of publication Amsterdam, Netherlands
Publisher Elsevier Science
Collection year 2005
Language eng
Subject C1
270104 Membrane Biology
780106 Political science and public policy
Abstract A number of recent studies have provided new insights into the complexity of the endocytic pathways originating at the plasma membrane of mammalian cells. Many of the molecules involved in clathrin coated pit internalization are now well understood but other pathways are less well defined. Caveolae appear to represent a low capacity but highly regulated pathway in a restricted set of tissues in vivo. A third pathway, which is both clathrin- and caveolae-independent, may constitute a specialized high capacity endocytic pathway for lipids and fluid. The relationship of this pathway, if any, to macropinocytosis or to the endocytic pathways of lower eukaryotes remains an interesting open question. Our understanding of the regulatory mechanisms and molecular components involved in this pathway are at a relatively primitive stage. In this review, we will consider some of the characteristics of different endocytic pathways in high and lower eukaryotes and consider some of the common themes in endocytosis. One theme which becomes apparent from comparison of these pathways is that apparently different pathways can share common molecular machinery and that pathways considered to be distinct actually represent similar basic pathways to which additional levels of regulatory complexity have been added. (c) 2005 Elsevier B.V. All rights reserved.
Keyword Endocytosis
Lipid Raft
Caveolae
Cholesterol
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Erratum: Biochimica et Biophysica Acta (issue 1746 (2005) pg 349)

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
ERA 2012 Admin Only
Institute for Molecular Bioscience - Publications
 
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Created: Wed, 15 Aug 2007, 15:47:21 EST