Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators

Garrec, R. B. L., Benoit, E., Sauviat, M. P., Lewis, R. J., Molgo, J. and Laurent, D (2005) Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators. Toxicon, 46 6: 625-634.


Author Garrec, R. B. L.
Benoit, E.
Sauviat, M. P.
Lewis, R. J.
Molgo, J.
Laurent, D
Title Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators
Journal name Toxicon  (ERA 2012 Listed)    (ERA 2010 Rank B)   Check publisher's open access policy
Publication date 2005
Sub-type Article
DOI 10.1016/j.toxicon.2005.07.002
Volume number 46
Issue number 6
ISSN 0041-0101
Start page 625
End page 634
Total pages 10
Editor Alan Harvey
Place of publication Oxford
Publisher Pergamon-Elsevier Science Ltd
Collection year 2005
Language eng
Subject C1
Abstract The effects of 31 plant extracts, which most are traditionally used to treat ciguatera fish poisoning in the Pacific area, were Studied on the cytotoxicity of mouse neuroblastoma cells produced by ouabain, veratridine and/or brevetoxin-3 or Pacific ciguatoxin-1. The cell viability was determined using a quantitative colorimetric method. A marked cytotoxicity of seven of the 31 plant extracts studied, was observed. Despite this, these plant extracts were suspected to contain active compound(s) against the cytotoxicity produced by brevetoxin (2 extracts), brevetoxin, ouabain and/or veratridine (3 extracts), or only against that of ouabain and/or veratridine (2 extracts). Among the 24 plant extracts that exhibited by themselves no cytotoxicity, 22 were active against the effect of brevetoxin or against that of both veratridine and brevetoxin. similar results were obtained when the seven most active plant extracts were reassayed using ciguatoxin instead of brevetoxin. In conclusion, the present work reports the first activity assessment of some plant extracts, achieved in vitro on a quite large scale. The fact that 27 plant extracts were found to exert, in vitro, a protective effect against the action of ciguatoxin and/or brevetoxin, paves the way for finding new active compounds to treat ciguatera fish poisoning, provided these compounds also reverse the effects of sodium channel activators. (c) 2005 Elsevier Ltd. All rights reserved.
Keyword Pharmacology & Pharmacy
Toxicology
Ciguatera Fish Poisoning
Treatment
Traditional Retnedies
Neuroblastoma Cell Assays
Voltage-sensitive Sodium Channels
Brevetoxin
Ciguatoxin
Veratridine
Colorimetric Assay
Euphorbia-hirta
Ciguatoxins
Brevetoxins
Mannitol
Saxitoxins
Pacific
Q-Index Code C1

 
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