Chronic kidney disease and automatic reporting of estimated glomerular filtration rate: a position statement

Anavekar, Nagesh, Bais, Renze, Carney, Shane, Davidson, James, Eris, Josette, Gallagher, Martin, Johnson, David, Jones, Graham, Sikaris, Ken, Lonergan, Maureen, Ludlow, Marie, Mackie, James, Mathew, Tim, May, Steve, McBride, Grant, Meerkin, Matthew, Peake, Michael, Power, David, Snelling, Paul, Voss, David and Walker, Rowan (2005) Chronic kidney disease and automatic reporting of estimated glomerular filtration rate: a position statement. Medical Journal of Australia, 183 3: 138-141.

Author Anavekar, Nagesh
Bais, Renze
Carney, Shane
Davidson, James
Eris, Josette
Gallagher, Martin
Johnson, David
Jones, Graham
Sikaris, Ken
Lonergan, Maureen
Ludlow, Marie
Mackie, James
Mathew, Tim
May, Steve
McBride, Grant
Meerkin, Matthew
Peake, Michael
Power, David
Snelling, Paul
Voss, David
Walker, Rowan
Title Chronic kidney disease and automatic reporting of estimated glomerular filtration rate: a position statement
Journal name Medical Journal of Australia   Check publisher's open access policy
ISSN 0025-729X
Publication date 2005-08-01
Sub-type Article (original research)
Volume 183
Issue 3
Start page 138
End page 141
Total pages 4
Place of publication Sydney
Publisher Australasian Medical Publishing Company
Collection year 2005
Language eng
Subject CX
730118 Organs, diseases and abnormal conditions not elsewhere classified
110312 Nephrology and Urology
Formatted abstract
• The systematic staging of chronic kidney disease (CKD) by glomerular filtration measurement and proteinuria has allowed the development of rational and appropriate management plans.
• One of the barriers to early detection of CKD is the lack of a precise, reliable and consistent measure of kidney function.
• The most common measure of kidney function is currently serum creatinine concentration. It varies with age, sex, muscle mass and diet, and interlaboratory variation between measurements is as high as 20%.
• The reference interval for serum creatinine concentration includes up to 25% of people (particularly thin, elderly women) who have an estimated glomerular filtration rate (eGFR) that is significantly reduced (<60mL/min/1.73m2).
• The recent publication of a validated formula (MDRD) to estimate GFR from age, sex, race and serum creatinine concentration, without any requirement for measures of body mass, allows pathology laboratories to “automatically” generate eGFR from data already acquired.
• Automatic laboratory reporting of eGFR calculated from serum creatinine measurements would help to identify asymptomatic kidney dysfunction at an earlier stage.
• eGFR correlates well with complications of CKD and an increased risk of adverse outcomes such as cardiovascular morbidity and mortality.
• We recommend that pathology laboratories automatically report eGFR each time a serum creatinine test is ordered in adults.
• As the accuracy of eGFR is suboptimal in patients with normal or near-normal renal function, we recommend that calculated eGFRs above 60mL/min/1.73m2 be reported by laboratories as “>60mL/min/1.73m2”, rather than as a precise figure.
Q-Index Code CX
Additional Notes A position statement by "Members of The Australasian Creatinine Consensus Working Group" as listed in the author fields.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Created: Wed, 15 Aug 2007, 05:45:03 EST