Promising results of a cooperative group phase II trial of preoperative chemoradiation for locally advanced rectal cancer (TROG 9801)

Ngan, S. Y. K., Fisher, R., Burmeister, B. H., Mackay, J., Goldstein, D., Kneebone, A., Schache, D., Joseph, D., McKendrick, J., Leong, T., McClure, B. and Rischin, D. (2005) Promising results of a cooperative group phase II trial of preoperative chemoradiation for locally advanced rectal cancer (TROG 9801). Diseases of The Colon & Rectum, 48 7: 1389-1396. doi:10.1007/s10350-005-0032-x


Author Ngan, S. Y. K.
Fisher, R.
Burmeister, B. H.
Mackay, J.
Goldstein, D.
Kneebone, A.
Schache, D.
Joseph, D.
McKendrick, J.
Leong, T.
McClure, B.
Rischin, D.
Title Promising results of a cooperative group phase II trial of preoperative chemoradiation for locally advanced rectal cancer (TROG 9801)
Journal name Diseases of The Colon & Rectum   Check publisher's open access policy
ISSN 0012-3706
Publication date 2005-07
Sub-type Article (original research)
DOI 10.1007/s10350-005-0032-x
Volume 48
Issue 7
Start page 1389
End page 1396
Total pages 8
Place of publication United Sates
Publisher Lippincott Willams & Wilkins
Collection year 2005
Language eng
Subject C1
321015 Oncology and Carcinogenesis
730108 Cancer and related disorders
1103 Clinical Sciences
1112 Oncology and Carcinogenesis
Abstract PURPOSE: This article reports the overall survival, failure-free survival, local failure, and late radiation toxicity of a phase II trial of preoperative radiotherapy with continuous infusion 5-fluorouracil for rectal cancer after a minimum 3.5 years of follow-up. METHODS: Eligible patients were those with newly diagnosed localized adenocarcinoma of the rectum, within 12 cm of the anal verge, staged T3-T4 and deemed suitable for curative resection. Radiotherapy (50.4 Gy in 28 fractions in five weeks and three days) was given with continuous infusion 5-fluorouracil throughout the course of radiotherapy. RESULTS: A total of 82 patients were accrued in 13 months. The median follow-up time was 4.1 (range, 2.3-4.5) years. There were 55 males (67 percent) and the median age was 59 (range, 27-87) years. Patients were staged pretreatment as T3 (89 percent) and resectable T4 (11 percent). Endorectal ultrasound was performed in 70 percent and magnetic resonance imaging in another 5 percent. The four-year overall and failure-free survival rates were 82 percent (95 percent Cl: 72-89) and 69 percent (95 percent Cl: 58-78), respectively. The cumulative incidence of local failure at four years was 3.9 percent (95 percent CI: 1.3-11). Risk of failures, local and distant, has not reached a plateau phase. CONCLUSION: This regimen can be delivered safely and without leading to a significant increase in late toxicity. It provides excellent local control and favorable overall survival. There is a need for longer follow-up than has commonly been used for the proper evaluation of failures after an effective regimen of preoperative chemoradiation.
Keyword Gastroenterology & Hepatology
Surgery
Rectal Cancer
Preoperative Radiotherapy
Chemoradiation
5fu
Total Mesorectal Excision
Term-follow-up
Radiation-therapy
Randomized Trials
Colorectal-cancer
Improved Survival
Adjuvant Therapy
Radiotherapy
Carcinoma
Chemoradiotherapy
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2006 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 05:39:05 EST