Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease

Mellick, George D., Maraganore, Demetrius M. and Silburn, Peter A. (2005) Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease. Neuroscience Letters, 375 2: 112-116. doi:10.1016/j.neulet.2004.10.078


Author Mellick, George D.
Maraganore, Demetrius M.
Silburn, Peter A.
Title Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
1872-7972
Publication date 2005
Sub-type Article (original research)
DOI 10.1016/j.neulet.2004.10.078
Volume 375
Issue 2
Start page 112
End page 116
Total pages 5
Editor M. Zimmermann
Place of publication Shannon, Co. Clare Ireland
Publisher Elsevier Ireland
Collection year 2005
Language eng
Subject C1
321013 Neurology and Neuromuscular Diseases
730104 Nervous system and disorders
Abstract It remains unclear whether genetic variants in SNCA (the alpha-synuclein gene) alter risk for sporadic Parkinson's disease (PD). The polymorphic mixed sequence repeat (NACP-Rep I) in the promoter region of SNCA has been previously examined as a potential susceptibility factor for PD with conflicting results. We report genotype and allele distributions at this locus from 369 PD cases and 370 control subjects of European Australian ancestry, with alleles designated as -1, 0, +1, +2, and +3 as previously described. Allele frequencies designated (0) were less common in Australian cases compared to controls (OR = 0.80, 95% CI 0.62-1.03). Combined analysis including all previously published ancestral European Rep1 data yielded a highly significant association between the 0 allele and a reduced risk for PD (OR = 0.79, 95% CI 0.70-0.89, p = 0.0001). Further study must now proceed to examine in detail this interesting and biologically plausible genetic association. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Keyword Neurosciences
Alpha-synuclein
Parkinson's Disease
Meta-analysis
Allelic Variation
Gene
Polymorphism
Susceptibility
Haplotypes
Mutation
Transcription
Genotype
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 05:37:35 EST