Impact of obesity on renal transplant outcomes

Armstrong, Kirsten A., Campbell, Scott B., Hawley, Carmel M., Johnson, David W. and Isbel, Nicole M. (2005) Impact of obesity on renal transplant outcomes. Nephrology, 10 4: 405-413. doi:10.1111/j.1440-1797.2005.00406.x


Author Armstrong, Kirsten A.
Campbell, Scott B.
Hawley, Carmel M.
Johnson, David W.
Isbel, Nicole M.
Title Impact of obesity on renal transplant outcomes
Journal name Nephrology   Check publisher's open access policy
ISSN 1320-5358
1440-1797
Publication date 2005
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1440-1797.2005.00406.x
Volume 10
Issue 4
Start page 405
End page 413
Total pages 9
Editor D. C. H. Harris
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2005
Language eng
Subject C1
730118 Organs, diseases and abnormal conditions not elsewhere classified
110312 Nephrology and Urology
Formatted abstract
Obesity is a frequent and important consideration to be taken into account when assessing patient suitability for renal transplantation. In addition, posttransplant obesity continues to represent a significant challenge to health care professionals caring for renal transplant recipients. Despite the vast amount of evidence that exists on the effect of pretransplant obesity on renal transplant outcomes, there are still conflicting views regarding whether obese renal transplant recipients have a worse outcome, in terms of short- and long-term graft survival and patient survival, compared with their non-obese counterparts. It is well established that any association of obesity with reduced patient survival in renal transplant recipients is mediated in part by its clustering with traditional cardiovascular risk factors such as hypertension, dyslipidaemia, insulin resistance and posttransplant diabetes mellitus, but what is not understood is what mediates the association of obesity with graft failure. Whether it is the higher incidence of cardiovascular comorbidities jeopardising the graft or factors specific to obesity, such as hyperfiltration and glomerulopathy, that might be implicated, currently remains unknown. It can be concluded, however, that pre- and posttransplant obesity should be targeted as aggressively as the more well-established cardiovascular risk factors in order to optimize long-term renal transplant outcomes.
Keyword Urology & Nephrology
Cardiovascular Risk Factors
Graft Function
Obesity
Renal Transplant Recipients
Transplant Outcomes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 05:30:39 EST