Molecular evolution of breast cancer

Simpson, P. T., Reis-Filho, J. S., Gale, T. and Lakhani, S. R. (2005) Molecular evolution of breast cancer. Journal of Pathology, 205 2: 248-254. doi:10.1002/path.1691


Author Simpson, P. T.
Reis-Filho, J. S.
Gale, T.
Lakhani, S. R.
Title Molecular evolution of breast cancer
Journal name Journal of Pathology   Check publisher's open access policy
ISSN 0022-3417
Publication date 2005-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/path.1691
Volume 205
Issue 2
Start page 248
End page 254
Total pages 7
Editor S. C. Herrington
Place of publication Chichester, U.K.
Publisher John Wiley
Collection year 2005
Language eng
Subject C1
321020 Pathology
730108 Cancer and related disorders
Abstract Molecular analysis of invasive breast cancer and its precursors has furthered our understanding of breast cancer progression. In the past few years, new multi-step pathways of breast cancer progression have been delineated through genotypic-phenotypic correlations. Nuclear grade, more than any other pathological feature, is strongly associated with the number and pattern of molecular genetic abnormalities in breast cancer cells. Thus, there are two distinct major pathways to the evolution of low- and high-grade invasive carcinomas: whilst the former consistently show oestrogen receptor (ER) and progesterone receptor (PgR) positivity and 16q loss, the latter are usually ER/PgR-negative and show Her-2 over-expression/amplification and complex karyotypes. The boundaries between the evolutionary pathways of well-differentiated/low-grade ductal and lobular carcinomas have been blurred, with changes in E-cadherin expression being one of the few distinguishing features between the two. In addition, lesions long thought to be precursors of breast carcinomas, such as hyperplasia of usual type, are currently considered mere risk indicators, whilst columnar cell lesions are now implicated as non-obligate precursors of atypical ductal hyperplasia (ADH) and well-differentiated ductal carcinoma in situ (DCIS). However, only through the combination of comprehensive morphological analysis and cutting-edge molecular tools can this knowledge be translated into clinical practice and patient management. Copyright (C) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley Sons, Ltd.
Keyword Pathology
Breast Cancer
Molecular Pathology
Evolution
Pathways
Cgh
Loh
Microarrays
Comparative Genomic Hybridization
Carcinoma In-situ
Pleomorphic Lobular Carcinoma
Different Genetic Pathways
Cytokeratin Expression Patterns
Atypical Ductal Hyperplasia
Allelic Imbalance
E-cadherin
Chromosomal-aberrations
Proliferative-lesions
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Health and Rehabilitation Sciences Publications
 
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Created: Wed, 15 Aug 2007, 15:25:09 EST