A critical role for the parabrachial nucleus in generating central nervous system responses elicited by a systemic immune challenge

Buller, KM, Allen, T, Wilson, LD, Munro, F and Day, TA (2004) A critical role for the parabrachial nucleus in generating central nervous system responses elicited by a systemic immune challenge. Journal of Neuroimmunology, 152 1-2: 20-32.


Author Buller, KM
Allen, T
Wilson, LD
Munro, F
Day, TA
Title A critical role for the parabrachial nucleus in generating central nervous system responses elicited by a systemic immune challenge
Journal name Journal of Neuroimmunology  (ERA 2012 Listed)    (ERA 2010 Rank B)   Check publisher's open access policy
Publication date 2004
Sub-type Article
DOI 10.1016/j.neuroim.2004.03.013
Volume number 152
Issue number 1-2
ISSN 0165-5728
Start page 20
End page 32
Total pages 13
Editor C.S Raine
Place of publication London UK
Publisher Elsevier
Collection year 2004
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract Using Fos immunolabelling as a marker of neuronal activation, we investigated the role of the parabrachial nucleus in generating central neuronal responses to the systemic administration of the proinflarnmatory cytokine interleukin-1beta (1 mug/kg, i.a.). Relative to intact animals, parabrachial nucleus lesions significantly reduced the number of Fos-positive cells observed in the central amygdala (CeA), the bed nucleus of the stria terminalis (BNST), and the ventrolateral medulla (VLM) after systemic interleukin-1beta. In a subsequent experiment in which animals received parabrachial-directed deposits of a retrograde tracer, it was found that many neurons located in the nucleus tractus solitarius (NTS) and the VLM neurons were both retrogradely labelled and Fos-positive after interleukin-1beta administration. These results suggest that the parabrachial nucleus plays a critical role in interleukin-1beta-induced Fos expression in CeA, BNST and VLM neurons and that neurons of the NTS and VLM may serve to trigger or at least influence changes in parabrachial nucleus activity that follows systemic interleukin-1beta administration. (C) 2004 Elsevier B.V. All rights reserved.
Keyword Immunology
Neurosciences
Bed Nucleus Of The Stria Terminalis
Central Amygdala
Interleukin-1 Beta
Nucleus Tractus Solitarius
Parabrachial Nucleus
Ventrolateral Medulla
Receptor Messenger-rna
Fos-like Immunoreactivity
Adrenal Axis Responses
Phaseolus-vulgaris Leukoagglutinin
Rat-brain
Stria Terminalis
Bed Nucleus
Solitary Tract
Paraventricular Nucleus
Interleukin-1 Receptor
Q-Index Code C1

 
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