Differential involvement of rat medial prefrontal cortex dopamine receptors in modulation of hypothalamic-pituitary-adrenal axis responses to different stressors

Spencer, SJ, Ebner, K and Day, TA (2004) Differential involvement of rat medial prefrontal cortex dopamine receptors in modulation of hypothalamic-pituitary-adrenal axis responses to different stressors. European Journal of Neuroscience, 20 4: 1008-1016. doi:10.1111/j.1460-9568.2004.03569.x


Author Spencer, SJ
Ebner, K
Day, TA
Title Differential involvement of rat medial prefrontal cortex dopamine receptors in modulation of hypothalamic-pituitary-adrenal axis responses to different stressors
Journal name European Journal of Neuroscience   Check publisher's open access policy
ISSN 1460-9568
Publication date 2004
Sub-type Article (original research)
DOI 10.1111/j.1460-9568.2004.03569.x
Volume 20
Issue 4
Start page 1008
End page 1016
Total pages 9
Editor B.J. Everitt
C.E Henderson
Place of publication UK
Publisher Blackwell Publishing
Collection year 2004
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract Recent investigations have implicated the medial prefrontal cortex (mPFC) in modulation of subcortical pathways that contribute to the generation of behavioural, autonomic and endocrine responses to stress. However, little is known of the mechanisms involved. One of the key neurotransmitters involved in mPFC function is dopamine, and we therefore aimed, in this investigation, to examine the role of mPFC dopamine in response to stress in Wistar rats. In this regard, we infused dopamine antagonists SCH23390 or sulpiride into the mPFC via retrodialysis. We then examined changes in numbers of cells expressing the c-fos immediate-early gene protein product, Fos, in subcortical neuronal populations associated with regulation of hypothalamic-pituitary-adrenal (HPA) axis stress responses in response to either of two stressors; systemic injection of interleukin-1beta, or air puff. The D-1 antagonist, SCH23390, and the D-2 antagonist, sulpiride, both attenuated expression of Fos in the medial parvocellular hypothalamic paraventricular nucleus (mpPVN) corticotropin-releasing factor cells at the apex of the HPA axis, as well as in most extra-hypothalamic brain regions examined in response to interleukin-1beta. By contrast, SCH23390 failed to affect Fos expression in response to air puff in any brain region examined, while sulpiride resulted in an attenuation of the air puff-induced response in only the mpPVN and the bed nucleus of the stria terminalis. These results indicate that the mPFC differentially processes the response to different stressors and that the two types of dopamine receptor may have different roles.
Keyword Neurosciences
Dopamine Receptors
Fos
Sch23390
Sulpiride
C-fos
Neurons
Neuroendocrine
Release
Lesions
Brain
D1
Interleukin-1-beta
Microdialysis
Excitability
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2005 Higher Education Research Data Collection
School of Biomedical Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 05:23:12 EST