Inhibition of 19-kDa C-terminal region of merozoite surface protein-1-specific antibody responses in neonatal pups by maternally derived 19-kDa C-terminal region of merozoite surface protein-1-specific antibodies but not whole parasite-specific antibodies

Stanisic, D. I., Martin, L. B., Gatton, M. L. and Good, M. F. (2004) Inhibition of 19-kDa C-terminal region of merozoite surface protein-1-specific antibody responses in neonatal pups by maternally derived 19-kDa C-terminal region of merozoite surface protein-1-specific antibodies but not whole parasite-specific antibodies. Journal of Immunology, 172 9: 5570-5581.


Author Stanisic, D. I.
Martin, L. B.
Gatton, M. L.
Good, M. F.
Title Inhibition of 19-kDa C-terminal region of merozoite surface protein-1-specific antibody responses in neonatal pups by maternally derived 19-kDa C-terminal region of merozoite surface protein-1-specific antibodies but not whole parasite-specific antibodies
Journal name Journal of Immunology   Check publisher's open access policy
ISSN 0022-1767
Publication date 2004
Sub-type Article (original research)
Volume 172
Issue 9
Start page 5570
End page 5581
Total pages 12
Editor R. Rich
Place of publication Bethesda, MD
Publisher American Association of Immunologists
Collection year 2004
Language eng
Subject C1
321299 Public Health and Health Services not elsewhere classified
730299 Public health not elsewhere classified
1107 Immunology
Abstract Immunizing pregnant women with a malaria vaccine is one approach to protecting the mother and her offspring from malaria infection. However, specific maternal Abs generated in response to vaccination and transferred to the fetus may interfere with the infant's ability to respond to the same vaccine. Using a murine model of malaria, we examined the effect of maternal 19-kDa C-terminal region of merozoite surface protein-1 (MSP1(19)) and Plasmodium yoelii Abs on the pups' ability to respond to immunization with MSP1(19). Maternal MSPI,g-specific Abs but not A yoelii-specific Abs inhibited Ab production following MSP1(19) immunization in 2-wk-old pups. This inhibition was correlated with the amount of maternal MSP1(19) Ab present in the pup at the time of immunization and was due to fewer specific B cells. Passively acquired Ab most likely inhibited the development of an Ab response by blocking access to critical B cell epitopes. If a neonate's ability to respond to MSP1(19) vaccination depends on the level of maternal Abs present at the time of vaccination, it may be necessary to delay immunization until Abs specific for the vaccinating Ag have decreased.
Keyword Immunology
Malaria Vaccine Trial
Plasmodium-falciparum
Immune-responses
Clinical Malaria
Dna Immunization
Pregnant-women
Mouse Muscle
Early-life
Mice Born
Infants
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2005 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 05:19:59 EST