Paternal and maternal age as risk factors for psychosis: findings from Denmark, Sweden and Australia

El-Saadi, Ossama, Pedersen, Carsten B., McNeil, Thomas F., Saha, Sukanta, Welham, Joy, O'Callaghan, Eadbhard, Cantor-Graae, Elizabeth, Chant, David, Mortensen, Preben Bo and McGrath, John (2004) Paternal and maternal age as risk factors for psychosis: findings from Denmark, Sweden and Australia. Schizophrenia Research, 67 2-3: 227-236. doi:10.1016/S0920-9964(03)00100-2

Author El-Saadi, Ossama
Pedersen, Carsten B.
McNeil, Thomas F.
Saha, Sukanta
Welham, Joy
O'Callaghan, Eadbhard
Cantor-Graae, Elizabeth
Chant, David
Mortensen, Preben Bo
McGrath, John
Title Paternal and maternal age as risk factors for psychosis: findings from Denmark, Sweden and Australia
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 0920-9964
Publication date 2004-04-01
Sub-type Article (original research)
DOI 10.1016/S0920-9964(03)00100-2
Volume 67
Issue 2-3
Start page 227
End page 236
Total pages 10
Editor H. A. Nasrallah
L. E. Delisi
Place of publication Netherlands
Publisher Elsevier BV
Collection year 2004
Language eng
Subject C1
321021 Psychiatry
730211 Mental health
Formatted abstract
Background: While the association between increased maternal age and congenital disorders has long been recognized, the offspring of older fathers are also at increased risk of congenital disorders related to DNA errors during spermatogenesis. Recent studies have drawn attention to an association between increased paternal age and increased risk of schizophrenia. The aim of the current study was to examine both paternal and maternal age as risk factors for the broader category of psychosis.

Method: We used data from three sources examining psychosis: a population-based cohort study (Denmark), and two case-control studies (Sweden and Australia).

Results: When controlling for the effect of maternal age, increased paternal age was significantly associated with increased risk of psychosis in the Danish and Swedish studies. The Australian study found no association between adjusted paternal age and risk of psychosis. When controlling for the effect of paternal age, younger maternal age was associated with an increased risk of psychoses in the Danish study alone.

Conclusions: The offspring of older fathers are at increased risk of developing psychosis. The role of paternally derived mutations and/or psychosocial factors associated with older paternal age warrants further research.
Keyword Paternal And Maternal Age
Congenital Disorders
De-novo Mutations
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 67 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 05:16:09 EST