Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study

McGrath, J, Saari, K, Hakko, H, Jokelainen, J, Jones, P, Jarvelin, MR, Chant, D and Isohanni, M (2004) Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study. Schizophrenia Research, 67 2-3: 237-245. doi:10.1016/j.schres.2003.08.005


Author McGrath, J
Saari, K
Hakko, H
Jokelainen, J
Jones, P
Jarvelin, MR
Chant, D
Isohanni, M
Title Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 0920-9964
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.1016/j.schres.2003.08.005
Volume 67
Issue 2-3
Start page 237
End page 245
Total pages 9
Editor H. A. Nasrallah
L. E. Delisi
Place of publication Netherlands
Publisher Elsevier BV
Collection year 2004
Language eng
Subject C1
321021 Psychiatry
730211 Mental health
Abstract Objective: Based on clues from epidemiology and animal experiments, low vitamin D during early life has been proposed as a risk factor for schizophrenia. The aim of this study was to explore the association between the use of vitamin D supplements during the first year of life and risk of developing schizophrenia. Method: Subjects were drawn from the Northern Finland 1966 Birth Cohort (n = 9 114). During the first year of life, data were collected about the frequency and dose of vitamin D supplementation. Our primary outcome measures were schizophrenia, psychotic disorders other than schizophrenia, and nonpsychotic disorders as diagnosed by age 31 years. Males and females were examined separately. Results: In males, the use of either irregular or regular vitamin D supplements was associated with a reduced risk of schizophrenia (Risk ratio (RR) = 0.08, 95% CI 0.01-0.95; RR = 0.12, 95% CI 0.02-0.90, respectively) compared with no supplementation. In males, the use of at least 2000 IU of vitamin D was associated with a reduced risk of schizophrenia (RR = 0.23, 95% CI 0.06-0.95) compared to those on lower doses. There were no significant associations between either the frequency or dose of vitamin D supplements and (a) schizophrenia in females, nor with (b) nonpsychotic disorder or psychotic disorders other than schizophrenia in either males or females. Conclusion: Vitamin D supplementation during the first year of life is associated with a reduced risk of schizophrenia in males. Preventing hypovitaminosis D during early life may reduce the incidence of schizophrenia. (C) 2003 Elsevier B.V. All rights reserved.
Keyword Schizophrenia
1,25-dihydroxyvitamin D-3
Brain Growth And Development
Northern Finland
Seasonal-variation
Prenatal Famine
Nervous-system
Follow-up
Body-mass
Pregnancy
Childhood
Brain
Psychiatry
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2005 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 15:16:05 EST