Maternal vitamin D3 deprivation and the regulation of apoptosis and cell cycle during rat brain development

Ko, Pauline, Burkert, Rachel, McGrath, John and Eyles, Darryl (2004) Maternal vitamin D3 deprivation and the regulation of apoptosis and cell cycle during rat brain development. Developmental Brain Research, 153 1: 61-68. doi:10.1016/j.devbrainres.2004.07.013


Author Ko, Pauline
Burkert, Rachel
McGrath, John
Eyles, Darryl
Title Maternal vitamin D3 deprivation and the regulation of apoptosis and cell cycle during rat brain development
Journal name Developmental Brain Research   Check publisher's open access policy
ISSN 0165-3806
1872-6755
Publication date 2004-10-15
Sub-type Article (original research)
DOI 10.1016/j.devbrainres.2004.07.013
Volume 153
Issue 1
Start page 61
End page 68
Total pages 8
Editor T. Curran
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2004
Language eng
Subject C1
321021 Psychiatry
730211 Mental health
1109 Neurosciences
1702 Cognitive Sciences
Formatted abstract
Recently, it has been shown that the prenatal vitamin D3 depletion is associated with altered brain development. Given the antiproliferative and pro-apoptotic properties of vitamin D3 in various cell types, we examined the effects of maternal vitamin D3 deprivation on cell proliferation and apoptosis within the rat cortex at several developmental stages. Our results confirm that vitamin D3 regulates these processes in the developing brain at both cellular and molecular levels. Compared to control animals, the embryos and pups from vitamin D3 depleted mothers had significantly less apoptotic cells, this finding being most pronounced at birth. Additionally, there were significantly more mitotic cells but this was not associated with any particular developmental period. Targeted gene arrays specific for apoptosis and cell cycle genes confirmed a pattern of transcription deregulation in the deplete group consistent with the known properties of vitamin D3. While most current vitamin D3 research is focussed on the pro-apoptotic and prodifferentiating properties of vitamin D3 as adjuncts for the treatment of cancers, our findings highlight the important role that this hormone plays in normal development via these same properties specifically in the brain.
(C) 2004 Elsevier B.V. All rights reserved.
Keyword Developmental biology
Neurosciences
Vitamin D-3
Apoptosis
Mitosis
Brain development
Macroarray
Breast-cancer cells
Hl-60 Leukemic-cells
1,25-dihydroxyvitamin D-3
Thyroid-hormone
In-vitro
Carcinoma-cells
Prostate-cancer
D Analogs
Expression
Growth
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 05:15:55 EST