Gene duplication and hierarchical modularity in intracellular interaction networks

Hallinan, J. (2004) Gene duplication and hierarchical modularity in intracellular interaction networks. Biosystems, 74 1-3: 51-62. doi:10.1016/j.biosystems.2004.02.004

Author Hallinan, J.
Title Gene duplication and hierarchical modularity in intracellular interaction networks
Journal name Biosystems   Check publisher's open access policy
ISSN 0303-2647
Publication date 2004
Sub-type Article (original research)
DOI 10.1016/j.biosystems.2004.02.004
Volume 74
Issue 1-3
Start page 51
End page 62
Total pages 12
Place of publication Ireland
Publisher Elsevier Ireland Ltd
Collection year 2004
Language eng
Subject C1
280210 Simulation and Modelling
780105 Biological sciences
Abstract Networks of interactions evolve in many different domains. They tend to have topological characteristics in common, possibly due to common factors in the way the networks grow and develop. It has been recently suggested that one such common characteristic is the presence of a hierarchically modular organization. In this paper, we describe a new algorithm for the detection and quantification of hierarchical modularity, and demonstrate that the yeast protein-protein interaction network does have a hierarchically modular organization. We further show that such organization is evident in artificial networks produced by computational evolution using a gene duplication operator, but not in those developing via preferential attachment of new nodes to highly connected existing nodes. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Keyword Biology
Gene Duplication
Protein-protein Interactions
Metabolic Networks
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2005 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 25 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 05:14:54 EST