Opioids Inhibit Lateral Amygdala Pyramidal Neurons by Enhancing A Dendritic Potassium Current

Faber, E. S. L. and Sah, P. (2004) Opioids Inhibit Lateral Amygdala Pyramidal Neurons by Enhancing A Dendritic Potassium Current. Journal of Neuroscience, 24 12: 3031-3039. doi:10.1523/JNEUROSCI.4496-03.2004

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Author Faber, E. S. L.
Sah, P.
Title Opioids Inhibit Lateral Amygdala Pyramidal Neurons by Enhancing A Dendritic Potassium Current
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2004
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.4496-03.2004
Open Access Status File (Publisher version)
Volume 24
Issue 12
Start page 3031
End page 3039
Total pages 9
Editor Gary L. Westbrook
Place of publication Washington D. C.
Publisher Society for Neuroscience
Collection year 2004
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract Pyramidal neurons in the lateral amygdala discharge trains of action potentials that show marked spike frequency adaptation, which is primarily mediated by activation of a slow calcium-activated potassium current. We show here that these neurons also express an alpha-dendrotoxin- and tityustoxin-Kalpha-sensitive voltage-dependent potassium current that plays a key role in the control of spike discharge frequency. This current is selectively targeted to the primary apical dendrite of these neurons. Activation of mu-opioid receptors by application of morphine or D-Ala(2)-N-Me-Phe(4)-Glycol(5)-enkephalin (DAMGO) potentiates spike frequency adaptation by enhancing the alpha-dendrotoxin-sensitive potassium current. The effects of mu-opioid agonists on spike frequency adaptation were blocked by inhibiting G-proteins with N-ethylmaleimide (NEM) and by blocking phospholipase A(2). Application of arachidonic acid mimicked the actions of DAMGO or morphine. These results show that mu-opioid receptor activation enhances spike frequency adaptation in lateral amygdala neurons by modulating a voltage-dependent potassium channel containing Kv1.2 subunits, through activation of the phospholipase A(2)-arachidonic acid-lipoxygenases cascade.
Keyword Anxiolytic
Arachidonic
Channel
Nociception
Pain
Lipoxygenase
Kvl.2
Long-term Potentiation
Tityustoxin-k-alpha
Periaqueductal Gray
Basolateral Amygdala
Hippocampal-neurons
Receptor Activation
Cortical-neurons
Arachidonic-acid
Rat-brain
Channels
Neurosciences
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 05:14:12 EST