Objective determination of appropriate reporting intervals

Badrick, Tony, Wilson, Susan R., Dimeski, Goce and Hickman, Peter E. (2004) Objective determination of appropriate reporting intervals. Annals of Clinical Biochemistry, 41 5: 385-390. doi:10.1258/0004563041731583

Author Badrick, Tony
Wilson, Susan R.
Dimeski, Goce
Hickman, Peter E.
Title Objective determination of appropriate reporting intervals
Journal name Annals of Clinical Biochemistry   Check publisher's open access policy
ISSN 0004-5632
Publication date 2004
Sub-type Article (original research)
DOI 10.1258/0004563041731583
Volume 41
Issue 5
Start page 385
End page 390
Total pages 6
Editor J. H. Barth
Place of publication London, United Kingdom
Publisher Royal Society of Medicine Press Ltd
Collection year 2004
Language eng
Subject CX
780101 Mathematical sciences
320201 Allergy
230204 Applied Statistics
321020 Pathology
730305 Diagnostic methods
Formatted abstract
Background: The reporting interval is the incremental value chosen in reporting analyte concentration. Reporting intervals for different analytes are often inappropriately narrow, when analytical imprecision and biological variability are considered.

Methods: We have used statistical techniques to determine intervals for individual analytes at which there is 50% or 95% confidence that two results are analytically different, and compared these with the reporting intervals in use for a range of general chemistry analytes and analytes usually measured by immunoassay.

Results: No analytes met the criteria for 95% confidence that the results are analytically different. Even at the 50% confidence level, 24 of 46 analytes failed at all concentrations examined. For some analytes, particularly hormones at high concentration, the reporting interval increment should be increased by a factor of at least ten.

Conclusions: The majority of analytes are inappropriately reported when analytical precision alone is considered. The concept of the 'uncertainty of measurement' has not been adequately addressed. A consensus should be reached and implemented on appropriate reporting intervals for all analytes.
Keyword Medical Laboratory Technology
Q-Index Code CX

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 05:10:49 EST