The comprehensive osteoarthritis test: a simple index for measurement of treatment effects in clinical trials

Brooks, LO, Rolfe, MI, Cheras, PA and Myers, SP (2004) The comprehensive osteoarthritis test: a simple index for measurement of treatment effects in clinical trials. Journal of Rheumatology, 31 6: 1180-1186.


Author Brooks, LO
Rolfe, MI
Cheras, PA
Myers, SP
Title The comprehensive osteoarthritis test: a simple index for measurement of treatment effects in clinical trials
Journal name Journal of Rheumatology   Check publisher's open access policy
ISSN 0315-162X
Publication date 2004
Sub-type Article (original research)
Volume 31
Issue 6
Start page 1180
End page 1186
Total pages 7
Editor Gordon DA
Pigott Y
Place of publication Canada
Publisher The Journal of Rheumatology Publishing Co. Ltd.
Collection year 2004
Language eng
Subject C1
321202 Epidemiology
730306 Evaluation of health outcomes
Abstract Objective. To assess the measurement properties of a simple index of symptom severity in osteoarthritis (OA) of the hips and knees. Methods. Both the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the proposed new Comprehensive Osteoarthritis Test (COAT) instrument were completed weekly by 125 subjects in the context of a randomized, 12-week, 3 parallel-arm clinical trial. The reliabilities of the various scales were assessed on a weekly basis by use of Cronbach's alpha coefficients. The validity of the COAT total scale was assessed by correlation with the WOMAC total scale on a weekly basis with correlation coefficients, and in terms of the correlations between subject-level intercepts and slopes over time. The relative responsiveness of the WOMAC and COAT total scales was assessed using a multilevel (longitudinal) multivariate (WOMAC, COAT) linear model. Results. The WOMAC and COAT total scales were highly reliable (mean over weeks: WOMAC alpha = 0.98; COAT alpha = 0.97). The correlations between the WOMAC and COAT scales were very high (mean over weeks = 0.92; subject-level intercepts = 0.91, slopes = 0.88). The COAT total scale was significantly more responsive than the WOMAC total scale in the active treatment (34.8% improvement vs 26.8%; p = 0.002). Conclusion. The COAT total scale is simple to administer, reliable, valid, and responsive to treatment effects.
Keyword Rheumatology
Comprehensive Osteoarthritis Test
Symptom Scale
Osteoarthritis
Validity
Reliability
Responsiveness
Visual Analog Scales
Pain
Validation
Arthritis
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2005 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 05:04:17 EST