Maintaining and updating semantic context in schizophrenia: an investigation of the effects of multiple remote primes

Chenery, H. J., Copland, D. A., McGrath, J. and Savage, G. (2004) Maintaining and updating semantic context in schizophrenia: an investigation of the effects of multiple remote primes. Psychiatry Research, 126 3: 241-252. doi:10.1016/j.psychres.2004.02.011


Author Chenery, H. J.
Copland, D. A.
McGrath, J.
Savage, G.
Title Maintaining and updating semantic context in schizophrenia: an investigation of the effects of multiple remote primes
Journal name Psychiatry Research   Check publisher's open access policy
ISSN 0165-1781
Publication date 2004-01-01
Sub-type Article (original research)
DOI 10.1016/j.psychres.2004.02.011
Volume 126
Issue 3
Start page 241
End page 252
Total pages 12
Editor M. S. Buchsbaum
Place of publication Amsterdam
Publisher Elsevier
Collection year 2004
Language eng
Subject C1
321204 Mental Health
730211 Mental health
Abstract Conflicting findings regarding the ability of people with schizophrenia to maintain and update semantic contexts have been due, arguably, to vagaries within the experimental design employed (e.g. whether strongly or remotely associated prime-target pairs have been used, what delay between the prime and the target was employed, and what proportion of related prime-target pairs appeared) or to characteristics of the participant cohort (e.g. medication status, chronicity of illness). The aim of the present study was to examine how people with schizophrenia maintain and update contextual information over an extended temporal window by using multiple primes that were either remotely associated or unrelated to the target. Fourteen participants with schizophrenia and 12 healthy matched controls were compared across two stimulus onset asynchronies (SOAs) (short and long) and two relatedness proportions (RP) (high and low) in a crossed design. Analysis of variance statistics revealed significant two- and three-way interactions between Group and SOA, Group and Condition, SOA and RP, and Group, SOA and RP. The participants with schizophrenia showed evidence of enhanced remote priming at the short SOA and low RP, combined with a reduction in the time course over which context could be maintained. There was some sensitivity to biasing contextual information at the short SOA, although the mechanism over which context served to update information appeared to be different from that in the controls. The participants with schizophrenia showed marked performance decrements at the long SOA (both low and high RP). Indices of remote priming at the short (but not the long) SOA correlated with both clinical ratings of thought disorder and with increasing length of illness. The results support and extend the hypothesis that schizophrenia is associated with concurrent increases in tonic dopamine activity and decreases in phasic dopamine activity. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Keyword Psychiatry
Language
Semantic Priming
Dopamine
Context
Lexical-decision
Thought-disorder
Word Pronunciation
Category Norms
Activation
Illness
Memory
Tasks
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 15:02:33 EST