Increased adjuvant activity of minimal CD8 T cell peptides incorporated into lipid-core-peptides

White, K., Kearns, P., Toth, I. and Hook, S. (2004) Increased adjuvant activity of minimal CD8 T cell peptides incorporated into lipid-core-peptides. Immunology And Cell Biology, 82 5: 517-522. doi:10.1111/j.1440-1711.2004.01269.x


Author White, K.
Kearns, P.
Toth, I.
Hook, S.
Title Increased adjuvant activity of minimal CD8 T cell peptides incorporated into lipid-core-peptides
Journal name Immunology And Cell Biology   Check publisher's open access policy
ISSN 0818-9641
Publication date 2004-10
Sub-type Article (original research)
DOI 10.1111/j.1440-1711.2004.01269.x
Volume 82
Issue 5
Start page 517
End page 522
Total pages 6
Place of publication Carlton
Publisher Blackwell Publishing Asia
Collection year 2004
Language eng
Subject C1
250302 Biological and Medical Chemistry
780105 Biological sciences
1107 Immunology
Abstract A problem facing the use of subunit peptide and protein vaccines is their inability to stimulate protective immune responses. Many different approaches have been utilized to overcome this inefficient immune activation. The approach we have taken is to modify the vaccine antigen so that it now has adjuvant properties. To do this, multiple copies of minimal CD8 T cell epitopes were attached to a poly lysine lipid core. These constructs are known as lipid-core-peptides (LCP). The research presented here examines the adjuvant activity of LCP. Using mouse models, we were able to show that LCP were indeed able to activate antigen-presenting cells in vitro and to activate cytotoxic T-cell responses in vivo. More importantly, LCP were able to stimulate the development of a protective antitumour immune response.
Keyword Cell Biology
Immunology
Cd8 T Cell
Lipid-core-peptide
Tumour
Vaccine
Toll-like Receptors
Dendritic Cells
Synthetic Peptides
Delivery-system
Lipopeptides
Antigen
Immunity
Protein
Innate
Help
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Pharmacy Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 05:01:58 EST