Blunted growth hormone response to clonidine in post-traumatic stress disorder

Morris, P, Hopwood, M, Maguire, K, Norman, T and Schweitzer, I (2004) Blunted growth hormone response to clonidine in post-traumatic stress disorder. Psychoneuroendocrinology, 29 2: 269-278. doi:10.1016/S0306-4530(03)00027-1


Author Morris, P
Hopwood, M
Maguire, K
Norman, T
Schweitzer, I
Title Blunted growth hormone response to clonidine in post-traumatic stress disorder
Journal name Psychoneuroendocrinology   Check publisher's open access policy
ISSN 0306-4530
Publication date 2004
Sub-type Article (original research)
DOI 10.1016/S0306-4530(03)00027-1
Volume 29
Issue 2
Start page 269
End page 278
Total pages 10
Editor R. Dantzer
N. H. Kalin
Place of publication UK
Publisher Elsevier Ltd
Collection year 2004
Language eng
Subject C1
321021 Psychiatry
730211 Mental health
Abstract Hyperactivity of the sympathetic and noradrenergic systems is thought to be a feature of post-traumatic stress disorder (PTSD). Assessment of noradrenergic receptor function can be undertaken by measuring the growth hormone (GH) response to the alpha(2)-agonist clonidine. The aim of this study was to examine whether subjects with combat-related PTSD (with or without co-morbid depression) have a blunted growth hormone response to clonidine, compared to a combat-exposed control group. Twenty-three Vietnam veterans suffering from PTSD alone, 27 suffering from PTSD and co-morbid depression, and 32 veteran controls with no psychiatric illness were administered 1.5 mug/kg clonidine i.v. Plasma growth hormone was measured every 20 min for 120 min. The growth hormone response to clonidine was significantly blunted in the non-depressed PTSD group compared to both the depressed PTSD group and the control group as measured by peak growth hormone, delta growth hormone and AUC growth hormone. Subjects with PTSD and no co-morbid depressive illness show a blunted growth hormone response to clonidine. This suggests that post-synaptic alpha(2)-receptors are subsensitive. This finding is consistent with other studies showing increased noradrenergic activity in PTSD. (C) 2003 Elsevier Ltd. All rights reserved.
Keyword Endocrinology & Metabolism
Neurosciences
Post-traumatic Stress Disorder
Depression
Growth Hormone
Clonidine
Noradrenaline
Neuroendocrine
Vietnam Combat Veterans
Catecholamine Excretion
Plasma Norepinephrine
Cortisol
Scale
Ptsd
Symptoms
Validity
Severity
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2005 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 04:50:21 EST