Post-transcriptional regulation of the cystic fibrosis gene in cardiac development and hypertrophy

Davies, W. L., Vandenberg, J. I., Sayeed, R. A. and Trezise, A. E. O. (2004) Post-transcriptional regulation of the cystic fibrosis gene in cardiac development and hypertrophy. Biochemical And Biophysical Research Communications, 319 2: 410-418. doi:10.1016/j.bbrc.2004.05.008


Author Davies, W. L.
Vandenberg, J. I.
Sayeed, R. A.
Trezise, A. E. O.
Title Post-transcriptional regulation of the cystic fibrosis gene in cardiac development and hypertrophy
Journal name Biochemical And Biophysical Research Communications   Check publisher's open access policy
ISSN 0006-291X
Publication date 2004
Sub-type Article (original research)
DOI 10.1016/j.bbrc.2004.05.008
Volume 319
Issue 2
Start page 410
End page 418
Total pages 9
Editor W. Baumeister
Place of publication United States
Publisher Academic Press
Collection year 2004
Language eng
Subject C1
270199 Biochemistry and Cell Biology not elsewhere classified
730110 Respiratory system and diseases (incl. asthma)
Abstract Eukaryotic gene expression, reflected in the amount of steady-state mRNA, is regulated at the post-transcriptional level. The 5'-untranslated regions (5'-UTRs) of some transcripts contain cis-acting elements, including upstream open reading frames (uORFs), that have been identified as being fundamental in modulating translation efficiency and mRNA stability. Previously, we demonstrated that uORFs present in the 5'-UTR of cystic fibrosis transmembrane conductance regular (CFTR) transcripts expressed in the heart were able to modulate translation efficiency of the main CFTR ORF. Here, we show that the same 5'-UTR elements are associated with the differential stability of the 5'-UTR compared to the main coding region of CFTR transcripts. Furthermore, these post-transcriptional mechanisms are important factors governing regulated CFTR expression in the heart, in response to developmental and pathophysiological stimuli. (C) 2004 Elsevier Inc. All rights reserved.
Keyword Biochemistry & Molecular Biology
Biophysics
Cardiac Hypertrophy
Cftr
Gene Expression
Mrna Stability
Uorf
Post-transcriptional Regulation
Cystic Fibrosis
Ion Channel
Cardiac Development
5 '-utr
Messenger-rna Stability
Open Reading Frames
Secondary Structure
Mammalian-cells
Translation
Expression
Identification
Initiation
Protein
Surveillance
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 04:47:05 EST