Mouse cellular cementum is highly dependent on growth hormone status

Smid, J. R., Rowland, J. E., Young, W. G., Daley, T. J., Coschigano, K. T., Kopchick, J. J. and Waters, M. J. (2004) Mouse cellular cementum is highly dependent on growth hormone status. Journal of Dental Research, 83 1: 35-39.

Author Smid, J. R.
Rowland, J. E.
Young, W. G.
Daley, T. J.
Coschigano, K. T.
Kopchick, J. J.
Waters, M. J.
Title Mouse cellular cementum is highly dependent on growth hormone status
Journal name Journal of Dental Research   Check publisher's open access policy
ISSN 0022-0345
Publication date 2004
Sub-type Article (original research)
Volume 83
Issue 1
Start page 35
End page 39
Total pages 5
Editor M. C. Herzberg
Place of publication USA
Publisher International and American Associations for Dental Research
Collection year 2004
Language eng
Subject C1
270106 Cell Development (incl. Cell Division and Apoptosis)
730112 Oro-dental and disorders
Abstract Cementum is known to be growth-hormone (GH)-responsive, but to what extent is unclear. This study examines the effects of extremes of GH status on cementogenesis in three lines of genetically modified mice; GH excess (giant), GH antagonist excess (dwarf), and GH receptor-deleted (GHR-KO) (dwarf). Age-matched mandibular molar tissues were processed for light microscope histology. Digital images of sections of first molar teeth were captured for morphometric analysis of lingual root cementum. Cross-sectional area of the cellular cementum was a sensitive guide to GH status, being reduced nearly 10-fold in GHR-KO mice, three-fold in GH antagonist mice, and increased almost two-fold in giant mice (p<0.001). Cellular cementum length was similarly influenced by GH status, but to a lesser extent. Acellular cementum was generally unaffected. This study reveals cellular cementum to be a highly responsive GH target tissue, which may have therapeutic applications in assisting regeneration of the periodontium.
Keyword Dentistry, Oral Surgery & Medicine
Growth Hormone
Gh Transgenic Mice
Gh Receptor Knockout Mice
Bone Morphogenetic Proteins
Transgenic Mice
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 04:46:13 EST