In vivo engineering of blood vessels

Daly,Chris D., Campbell, Gordon R., Walker, Philip J. and Campbell, Julie H. (2004) In vivo engineering of blood vessels. Frontiers In Bioscience, 9 2: 1915-1924. doi:10.2741/1384

Author Daly,Chris D.
Campbell, Gordon R.
Walker, Philip J.
Campbell, Julie H.
Title In vivo engineering of blood vessels
Journal name Frontiers In Bioscience   Check publisher's open access policy
ISSN 1093-9946
Publication date 2004-05
Sub-type Article (original research)
DOI 10.2741/1384
Volume 9
Issue 2
Start page 1915
End page 1924
Total pages 10
Editor S. Tabibzadeh
Place of publication Manhasset, NY, U.S.A.
Publisher Frontiers in Bioscience
Collection year 2004
Language eng
Subject C1
321003 Cardiology (incl. Cardiovascular Diseases)
730106 Cardiovascular system and diseases
0601 Biochemistry and Cell Biology
Formatted abstract
The inadequacy of conventional synthetic grafts has led to efforts to construct a superior vascular graft. In vivo tissue engineering is one approach to this problem that has been investigated for half a century and enables the construction of autogenous vascular prostheses. Three types of in vivo engineering are explored: remodelling of implanted scaffolds, fibrocollagenous tubes, and the artificial artery generated in the peritoneal cavity. Scaffolds designed to be remodelled may be synthetic or biological and have been remodelled in animal models to form vasoactive neoarteries with arterial morphology. The differences in vascular remodelling ability, particularly spontaneous endothelialisation, between animal models and humans may impair the effectiveness of this approach in the clinic. Fibrocollagenous tubes such as the Sparks' Mandril have demonstrated poor performance in the clinic and are prone to aneurysm formation. The artificial artery generated in the peritoneal cavity is a novel addition to the ranks of in vivo engineered vascular prostheses and combines many of the best features of scaffolds designed to be remodelled and fibrocollagenous tubes. However, understanding and manipulating the vascular remodelling process will be the key to producing the ideal arterial prosthesis.
Copyright © Frontiers in Bioscience, 1995
Keyword Biochemistry & Molecular Biology
Cell biology
Artificial artery
Vascular graft
Arterial prosthesis
In vivo
Tissue engineering
Autologous transplant
Fibrocollagenous tube
Caliber vascular grafts
Arterial-wall regeneration
Small-intestinal submucosa
Silicone mandril method
Fibrocollagenous tubes
Femoropopliteal bypass
Clinical experience
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 04:28:46 EST