Effect of inspiratory flow on methacholine challenge in children

Chang, Anne B., Wilson, Steve, Masters, Ian B., Harrhy, Hubbard and Hubbard, Melissa (2004) Effect of inspiratory flow on methacholine challenge in children. Journal of Asthma, 41 3: 349-354. doi:10.1081/JAS-120026094

Author Chang, Anne B.
Wilson, Steve
Masters, Ian B.
Harrhy, Hubbard
Hubbard, Melissa
Title Effect of inspiratory flow on methacholine challenge in children
Journal name Journal of Asthma   Check publisher's open access policy
ISSN 0277-0903
Publication date 2004
Sub-type Article (original research)
DOI 10.1081/JAS-120026094
Volume 41
Issue 3
Start page 349
End page 354
Total pages 6
Editor D. Tinkelman
B. Conner
Place of publication New York, U.S.
Publisher Marcel Dekker
Collection year 2004
Language eng
Subject C1
321019 Paediatrics
730110 Respiratory system and diseases (incl. asthma)
Abstract Regulation of inspiratory flow alters the outcomes of the methacholine (MHC) challenge in adults and cough receptor sensitivity in children. The effect of inspiratory flow on the reproducibility of the MHC challenge in children is unknown. The aim of this study was to evaluate the effect of inspiratory flow alteration on the repeatabilty of the MHC challenge in children with and without asthma. Twenty-five children undertook the MHC challenge on three different days by using a dosimeter connected to a setup that allowed regulation of inspiratory flow and pattern. Children were randomized to commence the challenges at 20 or 60 L/min, and the last challenge was performed at 20 L/min. The within-subject standard deviation, 95% range for change, and doubling dose for the differing inspiratory flow (20 vs. 60 L/min) was more than twice that of when inspiratory flow was maintained at 20 L/min for both occasions. The range of the limits of agreement of the Bland and Altman plot was smaller when inspiratory flow was constant. For short-term comparative individual studies in children, inspiratory flow should be regulated. Laboratories and research measuring change in airway hyperrepsonsiveness to MHC should determine and report reproducibility indices of the challenge so airway hyperresponsiveness changes can be interpreted meaningfully.
Keyword Allergy
Respiratory System
Inspiratory Flow
Airway Hyperresponsiveness
Bronchial Responsiveness
Inhalation Challenge
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 04:24:56 EST