Use of the P gene to genotype human metapneumovirus identifies 4 viral subtypes

Mackay, Ian M., Bialasiewiecz, Seweryn, Waliuzzaman, Zubair, Chidlow, Glenys R., Fegredo, David C., Laingam, Somprasong, Adamson, Penny, Harnett, Gerald B., Rawlinson, William, Nissen, Michael D. and Sloots, Theo P. (2004) Use of the P gene to genotype human metapneumovirus identifies 4 viral subtypes. Journal of Infectious Diseases, 190 11: 1913-1918. doi:10.1086/425013

Author Mackay, Ian M.
Bialasiewiecz, Seweryn
Waliuzzaman, Zubair
Chidlow, Glenys R.
Fegredo, David C.
Laingam, Somprasong
Adamson, Penny
Harnett, Gerald B.
Rawlinson, William
Nissen, Michael D.
Sloots, Theo P.
Title Use of the P gene to genotype human metapneumovirus identifies 4 viral subtypes
Journal name Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
Publication date 2004-12-01
Sub-type Article (original research)
DOI 10.1086/425013
Volume 190
Issue 11
Start page 1913
End page 1918
Total pages 6
Editor Martin S. Hirsch
Place of publication Chicago, IL, U.S.A.
Publisher The University of Chicago Press
Collection year 2004
Language eng
Subject C1
270303 Virology
730101 Infectious diseases
060506 Virology
1103 Clinical Sciences
0605 Microbiology
Formatted abstract
This study, conducted during 2001-2003, undertook the screening of patients with acute infectious respiratory-tract disease. A random selection of positive specimens was used for sequencing studies of the human metapneumovirus (hMPV) nucleoprotein gene and the phosphoprotein (P) gene. Australian and international sequences were compared, and a global classification scheme was developed. The hMPV P gene was an ideal molecular target for the detection and genotyping of hMPV. The region contained conserved sequences for reverse-transcriptase-polymerase chain-reaction primers and adequate variability to permit the accurate genotyping of the virus into 2 main lineages and 4 sublineages. Establishing viral identity is essential for the linking of genotype and disease severity.
© 2004 by the Infectious Diseases Society of America. All rights reserved.
Keyword P Gene
Human metapneumovirus
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 04:24:24 EST