Effect of cooling and re-warming on cerebral and whole body electrical impedance

Lingwood, B. E., Dunster, K. R., Healy, G. N. and Colditz, P. B. (2004) Effect of cooling and re-warming on cerebral and whole body electrical impedance. Physiological Measurement, 25 2: 413-420. doi:10.1088/0967-3334/25/2/001

Author Lingwood, B. E.
Dunster, K. R.
Healy, G. N.
Colditz, P. B.
Title Effect of cooling and re-warming on cerebral and whole body electrical impedance
Journal name Physiological Measurement   Check publisher's open access policy
ISSN 0967-3334
Publication date 2004
Sub-type Article (original research)
DOI 10.1088/0967-3334/25/2/001
Volume 25
Issue 2
Start page 413
End page 420
Total pages 8
Editor M. R. Neuman
Place of publication Bristol, U.K.
Publisher IOP Publishing
Collection year 2004
Language eng
Subject C1
321019 Paediatrics
730104 Nervous system and disorders
Abstract Cerebral electrical impedance is useful for the detection of cerebral edema following hypoxia in newborn infants. Thus it may be useful for determining neurological outcome or monitoring treatment. Hypothermia is a promising new therapy currently undergoing trials, but will alter impedance measurements. This study aimed to define the relationship between temperature and both cerebral and whole body electrical impedance, and to derive correction factors for adjustment of impedance measurements during hypothermia. In eight anaesthetized 1-2 day old piglets rectal, tympanic and scalp temperatures were monitored continuously. Following baseline readings at a rectal temperature of 39degreesC, piglets were cooled to 32degreesC. Four piglets were re-warmed. Cerebral and whole body impedance were measured at each 0.5degreesC as rectal temperature decreased. There was a strong linear relationship between both cerebral and whole body impedance and each of the temperatures measured. There was no difference in the relationship between impedance and rectal, tympanic or scalp temperatures. The relationship for impedance and rectal temperature was the same during cooling and re-warming. Using the correction factors derived it will be possible to accurately monitor cerebral and whole body fluid distribution during hypothermic treatment.
Keyword Biophysics
Engineering, Biomedical
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 04:20:50 EST